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   Articles with "ketogenesis" as a keyword



Maladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CB1R Contributes to Diabetic Neuropathy

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202414547

Abstract: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Although studies have previously investigated metabolic disruptions in the peripheral nervous system (PNS), the exact metabolic mechanisms underlying DPN remain largely unknown. Herein, a… read more here.

Keywords: ketogenesis; schwann cells; peripheral ketogenesis; ketogenesis schwann ... See more keywords
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Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

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recommendations! Published in 2022 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2022.101494

Abstract: Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development of the… read more here.

Keywords: ketogenesis; hmgcs2; development; hmgcs2 mediated ... See more keywords

Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/4253651

Abstract: As heart failure develops, the heart utilizes ketone bodies at increased rates, indicating an adaptive stress response. Thus, increasing ketone body availability exerts protective effects against heart failure. However, although it is the widely used… read more here.

Keywords: ketogenesis; heart failure; tac mice; heart ... See more keywords

Ketogenesis attenuates KLF5-dependent production of CXCL12 to overcome the immunosuppressive tumor microenvironment in colorectal cancer.

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recommendations! Published in 2022 at "Cancer research"

DOI: 10.1158/0008-5472.can-21-2778

Abstract: The dynamic composition of the tumor microenvironment (TME) can markedly alter the response to targeted therapies for colorectal cancer (CRC). Cancer associated fibroblasts (CAF) are major components of TMEs that can direct and induce infiltration… read more here.

Keywords: ketogenesis; tme; tumor microenvironment; colorectal cancer ... See more keywords

Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy

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recommendations! Published in 2018 at "Diabetes"

DOI: 10.2337/db18-117-lb

Abstract: Enthusiasm for SGLT2 inhibitors as adjunctive agents for T1D has been tempered by increased risk of DKA, especially in pump treated patients susceptible to interruptions of basal insulin due to infusion site failures. Our insulin… read more here.

Keywords: ketogenesis; sglt2; ketogenesis type; suppression ketogenesis ... See more keywords

Intact ketogenesis predicted reduced risk of moderate-severe metabolic-associated fatty liver disease assessed by liver transient elastography in newly diagnosed type 2 diabetes

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recommendations! Published in 2024 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2023.1306134

Abstract: Aim Hepatic ketogenesis is a key metabolic pathway that regulates energy homeostasis. Some related controversies exist regarding the pathogenesis of metabolic-associated fatty liver disease (MAFLD). We aimed to investigate whether intact ketogenic capacity could reduce… read more here.

Keywords: moderate severe; risk moderate; newly diagnosed; ketogenesis ... See more keywords

Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.667673

Abstract: The dysregulation of epigenetic modification and energy metabolism cooperatively contribute to the tumorigenesis of nasopharyngeal carcinoma (NPC). However, the detailed mechanisms underlying their joint contribution to NPC development and progression remain unclear. Here, we investigate… read more here.

Keywords: acetyl coa; npc; proliferation metastasis; ketogenesis ... See more keywords

Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

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recommendations! Published in 2025 at "Biomolecules"

DOI: 10.3390/biom15081181

Abstract: Patients with concurrent non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) exhibit increased susceptibility to non-alcoholic steatohepatitis (NASH), advanced hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. This study investigated the contribution of ketogenesis… read more here.

Keywords: t2dm; hmgcs2; ketogenesis; nafld progression ... See more keywords

Ketone Body Induction: Insights into Metabolic Disease Management

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recommendations! Published in 2025 at "Biomedicines"

DOI: 10.3390/biomedicines13061484

Abstract: Ketone bodies (KBs), particularly β-hydroxybutyrate, are crucial metabolites that provide clean and efficient energy, especially during periods of low glucose availability. Ketogenesis is a promising therapeutic avenue for conditions such as obesity, metabolic syndrome, and… read more here.

Keywords: insights metabolic; induction insights; ketogenesis; body induction ... See more keywords

Intestinal Ketogenesis and Permeability

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25126555

Abstract: Consumption of a high-fat diet (HFD) has been suggested as a contributing factor behind increased intestinal permeability in obesity, leading to increased plasma levels of microbial endotoxins and, thereby, increased systemic inflammation. We and others… read more here.

Keywords: intestinal ketogenesis; permeability; ketogenesis; expression ... See more keywords

The Impact of Ketogenic Capacity on Lipid Profile in Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26178566

Abstract: In individuals with non-adipogenic traits and enhanced ketogenic capacity, plasma triglyceride (TG) levels are typically low, while low-density lipoprotein cholesterol (LDL-C) levels often exceed the normal range, complicating cardiovascular risk assessment. We analyzed lipid profiles… read more here.

Keywords: enhanced ketogenesis; newly diagnosed; ketogenesis; type diabetes ... See more keywords