Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.093
Abstract: The human mitochondrial alpha-ketoglutarate (α-KG) dehydrogenase complex (hKGDHc) is a well-studied macromolecular enzyme that converts α-KG to succinyl-CoA and NADH. Abnormalities of the complex lead to several diseases, including neurodegenerative disorders. Despite its importance in… read more here.
Keywords: regulation human; activity regulation; structural basis; dehydrogenase ... See more keywords
The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11040321
Abstract: There is increasing evidence that several mitochondrial abnormalities are present in the brains of patients with Alzheimer’s disease (AD). Decreased alpha-ketoglutarate dehydrogenase complex (αKGDHc) activity was identified in some patients with AD. The αKGDHc is… read more here.
Keywords: alpha ketoglutarate; variants genes; alzheimer disease; ketoglutarate dehydrogenase ... See more keywords