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   Articles with "ketoglutarate dependent" as a keyword



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Investigations on the role of a solvent tunnel in the α-ketoglutarate dependent oxygenase factor inhibiting HIF (FIH).

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recommendations! Published in 2018 at "Journal of inorganic biochemistry"

DOI: 10.1016/j.jinorgbio.2017.10.001

Abstract: Non-heme Fe(II)/α-ketoglutarate (αKG)-dependent oxygenases catalyze a wide array of reactions through coupling oxidative decarboxylation of αKG to substrate oxygenation. This class of enzymes follows a sequential mechanism in which O2 reacts only after binding primary… read more here.

Keywords: ketoglutarate dependent; tunnel; factor inhibiting; factor ... See more keywords
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Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases.

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00115

Abstract: Fe(II)/α-ketoglutarate-dependent dioxygenases (α-KGDs) are widespread enzymes in aerobic biology and serve a remarkable array of biological functions, including roles in collagen biosynthesis, plant and animal development, transcriptional regulation, nucleic acid modification, and secondary metabolite biosynthesis.… read more here.

Keywords: engineering ketoglutarate; ketoglutarate dependent; biology; engineering ... See more keywords
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Non-Native Anionic Ligand Binding and Reactivity in Engineered Variants of the Fe(II)- and α-Ketoglutarate-Dependent Oxygenase, SadA.

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recommendations! Published in 2022 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.2c02872

Abstract: Mononuclear non-heme Fe(II)- and α-ketoglutarate-dependent oxygenases (FeDOs) catalyze a site-selective C-H hydroxylation. Variants of these enzymes in which a conserved Asp/Glu residue in the Fe(II)-binding facial triad is replaced by Ala/Gly can, in some cases,… read more here.

Keywords: ketoglutarate dependent; ligand; facial triad; rebound ... See more keywords
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Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c08116

Abstract: Non-heme iron enzymes are versatile catalysts in the biosynthesis of medicinal natural products and have attracted increasing attention as practical catalytic tools in chemical synthesis due to their ability to perform chemically challenging transformations. The… read more here.

Keywords: substrate specificity; ketoglutarate dependent; tqal; dependent oxygenase ... See more keywords
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Structural and Functional Insights into a Nonheme Iron- and α-Ketoglutarate-Dependent Halogenase That Catalyzes Chlorination of Nucleotide Substrates

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recommendations! Published in 2022 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.02497-21

Abstract: Halogenated nucleotides are a group of important antibiotics and are clinically used as antiviral and anticancer drugs. AdeV is the first carrier protein-independent nonheme iron- and α-ketoglutarate (αKG)-dependent halogenase (NHFeHal) that can selectively halogenate nucleotides… read more here.

Keywords: adev; iron ketoglutarate; ketoglutarate dependent; nonheme iron ... See more keywords