Mechanism and Inhibitor Exploration with Binuclear Mg Ketol‐Acid Reductoisomerase: Targeting the Biosynthetic Pathway of Branched‐Chain Amino Acids
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DOI: 10.1002/cbic.201900363
Abstract: Binuclear Mg ketol‐acid reductoisomerase (KARI), which converts (S)‐2‐acetolactate into (R)‐2,3‐dihydroxyisovalerate, is responsible for the second step of the biosynthesis of branched‐chain amino acids in plants and microorganisms and thus serves as a key inhibition target… read more here.
Keywords: binuclear ketol; mechanism; chain amino; branched chain ... See more keywords
Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
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DOI: 10.2210/pdb6jcv/pdb
Abstract: While cryo-EM is revolutionizing structural biology, its impact on enzymology is yet to be fully demonstrated. The ketol-acid reductoisomerase (KARI) catalyzes conversion of (2S)-acetolactate or (2... read more here.
Keywords: cryo uncover; acid reductoisomerase; ketol acid; use cryo ... See more keywords