Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid production
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DOI: 10.1007/s00253-019-09668-4
Abstract: Abstract7-Ketolithocholic acid (7-KLCA) is an important intermediate for the synthesis of ursodeoxycholic acid (UDCA). UDCA is the main effective component of bear bile powder that is used in traditional Chinese medicine for the treatment of… read more here.
Keywords: tolerance; ketolithocholic acid; directed evolution; hydroxysteroid dehydrogenase ... See more keywords