The contribution of ketone bodies to glycolytic inhibition for the treatment of adult and pediatric glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03431-w
Abstract: Purpose Glioblastoma (GBM) remains one of the most lethal primary brain tumors in children and adults. Targeting tumor metabolism has emerged as a promising-targeted therapeutic strategy for GBM and characteristically resistant GBM stem-like cells (GSCs).… read more here.
Keywords: gbm; treatment; ketone; adult pediatric ... See more keywords
Efficient synthesis of the ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.010
Abstract: The ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer were prepared in a short, operationally simple synthetic sequence from racemic β-butyrolactone. Enantioselective hydrolysis of β-butyrolactone with immobilized Candida antarctica lipase-B (CAL-B) results in (R)-β-butyrolactone and… read more here.
Keywords: ester hydroxybutyryl; ketone; ketone body; hydroxybutyrate ... See more keywords
Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2017.06.009
Abstract: Abstract Ketone bodies are small lipid-derived molecules and the metabolism of ketone bodies interfaces with various physiological processes. 3-Hydroxybutyric acid (3HB) is the most stable ketone body and can be employed to supply energy source.… read more here.
Keywords: 2hb 3hb; ketone; chiral derivatization; coupled liquid ... See more keywords
Allyloxy ketones as efficient photoinitiators with high migration stability in free radical polymerization and 3D printing
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108900
Abstract: Five ketone derivatives(ketone-1~ketone-5) never synthesized in the literature and containing the same peripheral 1,3-bis(allyloxy)benzene substitutinggroup but different central cyclohexanone cores were designed and proposed as high-performance photoinitiators for the free radical polymerizationof acrylates under mild… read more here.
Keywords: free radical; ketone ketone; ketone; efficient photoinitiators ... See more keywords
Ionic crosslinking of imidazolium functionalized poly(aryl ether ketone) by sulfonated poly(ether ether ketone) for anion exchange membranes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2017.03.033
Abstract: Two N3-substituted imidazoles 1,2-dimethylimidazole and 1-butyl-2-methylimidazole were chosen to functionalize poly(aryl ether ketone), respectively. The generated imidazolium cations could electrostatically react with sulfonate ions of the sulfonated poly(ether ether ketone) forming the ionic crosslinking structure… read more here.
Keywords: aryl ether; ether ketone; ketone; exchange ... See more keywords
Accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2021.108030
Abstract: OBJECTIVE To assess the accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes. RESEARCH DESIGN AND METHODS This is a proof-of-concept, prospective study comparing breath ketone analyzer… read more here.
Keywords: breath ketone; ketone analyzer; detect ketosis; ketone ... See more keywords
Long-term ketone body therapy of severe multiple acyl-CoA dehydrogenase deficiency: A case report.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2018.10.014
Abstract: OBJECTIVES Multiple acyl-CoA dehydrogenase deficiency (MADD) is the most severe disorder of mitochondrial fatty acid β-oxidation. Treatment of this disorder is difficult because the functional loss of the electron transfer flavoprotein makes energy supply from… read more here.
Keywords: term; long term; ketone; coa ... See more keywords
Simple one pot synthesis of ketone from carboxylic acid using DCC as an activator
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.04.030
Abstract: Abstract Simple one pot procedure for the conversion of carboxylic acid to ketone is described. Various carboxylic acids were converted to the corresponding ketones in excellent manner in presence of N,N′-dicyclohexylcarbodiimide (DCC) and organometallic reagents.… read more here.
Keywords: ketone; one pot; simple one; carboxylic acid ... See more keywords
One-Electron Oxidant-Induced Transformations of Aromatic Alcohol to Ketone Moieties in Dissolved Organic Matter Increase Trichloromethane Formation.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c06425
Abstract: Radicals in advanced oxidation processes (AOPs) degrade micropollutants during water and wastewater treatment, but the transformation of dissolved organic matter (DOM) may be equally important. Ketone moieties in DOM are known disinfection byproduct precursors, but… read more here.
Keywords: one electron; ketone; aromatic alcohol; electron ... See more keywords
Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00110
Abstract: A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acid is developed. Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on… read more here.
Keywords: ketone suzuki; ketone; coupling reaction; suzuki miyaura ... See more keywords
A Highly Salt-Soluble Ketone-Based All-Solid-State Polymer Electrolyte with Superior Performances for Lithium-Ion Batteries.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c22228
Abstract: Solid polymer electrolytes (SPEs) have great potential to be used in high-safety lithium-ion batteries (LIBs). However, it is still a significant challenge for SPEs to develop high ionic conductivity, high mechanical strength, and good interior… read more here.
Keywords: polymer; ketone; solid state; lithium ... See more keywords