Comments on “Inhibition of the ketolytic acetyl CoA supply to tumors could be their ‘Achilles heel’”
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33017
Abstract: Dear editor, In an interesting letter published recently in this journal, Drs Israël and Schwartz hypothesize that the breakdown of ketone bodies is a tumor cell's “unique source of mitochondrial acetyl CoA”. They propose to… read more here.
Keywords: tumor; coa; acetyl coa; cell ... See more keywords
Postmortem 1H-MRS—Detection of Ketone Bodies and Glucose in Diabetic Ketoacidosis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-017-1741-0
Abstract: Diabetic ketoacidosis (DKA) is a metabolic complication of diabetes mellitus that takes a lethal course if untreated. In this way relevant to forensic medicine, secure diagnosis of DKA usually involves the evidence of elevated levels… read more here.
Keywords: medicine; postmortem mrs; diabetic ketoacidosis; ketone bodies ... See more keywords
Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of forensic and legal medicine"
DOI: 10.1016/j.jflm.2018.07.009
Abstract: We report a fetal loss following maternal ketoacidosis in a case of cryptic pregnancy. Biochemical analysis of peripheral blood revealed highly elevated levels of beta-hydroxybutyrate (BHB) in the mother (9.2 mmol/l) and the fetus (4.2 mmol/l). Fetal… read more here.
Keywords: detection; fetal ketoacidosis; ketoacidosis; case ... See more keywords
Multi-dimensional Roles of Ketone Bodies in Cancer Biology: Opportunities for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104500
Abstract: Ketone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction and are applied in the treatment of epilepsy and other neurodegenerative diseases. Recently, people have paid more attention to its application in the treatment… read more here.
Keywords: roles ketone; multi dimensional; biology; cancer ... See more keywords
Circulating ketone bodies and cardiovascular outcomes: the MESA study.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehad087
Abstract: AIMS Ketone bodies (KB) are an important alternative metabolic fuel source for the myocardium. Experimental and human investigations suggest that KB may have protective effects in patients with heart failure. This study aimed to examine… read more here.
Keywords: ketone bodies; rate; mortality; cvd ... See more keywords
Circulating ketone bodies, genetic predisposition, and incident atrial fibrillation
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.455
Abstract: Ketone bodies (KB) are essential alternative fuel sources for the myocardium. However, the evidence on the level of circulating KB and heart disorders is inconsistent. Whether the total and individual KB are associated with risk… read more here.
Keywords: atrial fibrillation; risk; ketone bodies; genetic risk ... See more keywords
The janus face of ketone bodies in hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003243
Abstract: Hypertension is the most important risk factor for the development of terminal cardiovascular diseases, such as heart failure, chronic kidney disease, and atherosclerosis. Lifestyle interventions to lower blood pressure are generally desirable prior to initiating… read more here.
Keywords: janus face; ketone; ketone bodies; side effects ... See more keywords
Ketone bodies: A double-edged sword for mammalian life span.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13833
Abstract: Accumulating evidence suggests health benefits of ketone bodies, and especially for longevity. However, the precise role of endogenous ketogenesis in mammalian life span, and the safety and efficacy of the long-term exogenous supplementation of ketone… read more here.
Keywords: life span; edged sword; ketone bodies; mammalian life ... See more keywords
MEK1‐dependent MondoA phosphorylation regulates glucose uptake in response to ketone bodies in colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15667
Abstract: The Mondo family transcription factor MondoA plays a pivotal role in sensing metabolites, such as glucose, glutamine, and lactic acid, to regulate glucose metabolism and cell proliferation. Ketone bodies are important signals for reducing glucose… read more here.
Keywords: mondoa; ketone bodies; glucose uptake; phosphorylation ... See more keywords
Pioglitazone reduces serum ketone bodies in sodium‐glucose cotransporter‐2 inhibitor‐treated non‐obese type 2 diabetes: A single‐centre, randomized, crossover trial
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.1111/dom.15641
Abstract: To examine the effects of the thiazolidinedione (TZD) pioglitazone on reducing ketone bodies in non‐obese patients with T2DM treated with the sodium‐glucose cotransporter‐2 (SGLT2) inhibitor canagliflozin. read more here.
Keywords: ketone bodies; sodium glucose; non obese; glucose cotransporter ... See more keywords
Emerging pathophysiological roles of ketone bodies.
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.00031.2023
Abstract: The discovery of insulin approximately a century ago greatly improved the management of diabetes, including many of its life-threatening acute complications like ketoacidosis. This breakthrough saved many lives and extended the healthy lifespan of many… read more here.
Keywords: pathophysiological roles; physiology; ketone bodies; emerging pathophysiological ... See more keywords