Efficient synthesis of the ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.010
Abstract: The ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer were prepared in a short, operationally simple synthetic sequence from racemic β-butyrolactone. Enantioselective hydrolysis of β-butyrolactone with immobilized Candida antarctica lipase-B (CAL-B) results in (R)-β-butyrolactone and… read more here.
Keywords: ester hydroxybutyryl; ketone; ketone body; hydroxybutyrate ... See more keywords
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.07.012
Abstract: The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases. If not detoxified by the endogenous glyoxalase system, it exerts its detrimental effects primarily by reacting… read more here.
Keywords: body acetoacetate; ketosis; ketone body; non enzymatic ... See more keywords
The role of OXCT1 in the pathogenesis of cancer as a rate‐limiting enzyme of ketone body metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.07.003
Abstract: ABSTRACT Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3‐oxoacid CoA‐transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and… read more here.
Keywords: metabolism; enzyme ketone; ketone body; body metabolism ... See more keywords
Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31822-7
Abstract: The rapid decline in fertility that has been occurring to high-producing dairy cows in the past 50 years seems to be associated with metabolic disturbances such as ketosis, supporting the need for research to improve… read more here.
Keywords: epigenetic effects; ketone body; expression; body hydroxybutyrate ... See more keywords
Ketone body 3-hydroxybutyrate as a biomarker of aggression
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84635-6
Abstract: Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using… read more here.
Keywords: hydroxybutyrate biomarker; ketone; aggression; ketone body ... See more keywords
Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status?
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Endocrinology"
DOI: 10.1155/2017/9684061
Abstract: Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased… read more here.
Keywords: body levels; plasma; glucose levels; ketone body ... See more keywords
The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-022-01320-0
Abstract: Background Aseptic Loosening (AL) following periprosthetic osteolysis is the main long-term complication after total joint arthroplasty (TJA). However, there is rare effective treatment except for revision surgery, which is costly and painful to the patients.… read more here.
Keywords: hydroxybutyrate bhb; body hydroxybutyrate; ketone body; hydroxybutyrate ... See more keywords
Ketone body oxidation increases cardiac endothelial cell proliferation.
Sign Up to like & getrecommendations! Published in 2022 at "EMBO molecular medicine"
DOI: 10.15252/emmm.202114753
Abstract: Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essential substrates for ATP and biomass production; however, the metabolism of other substrates remains poorly understood. Ketone bodies are… read more here.
Keywords: cell proliferation; ketone body; cardiac endothelial; ketone ... See more keywords
34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-34-or
Abstract: Type 2 diabetes (T2D) is a rapidly growing health epidemic, with intense investigation on whether perturbations in skeletal muscle carbohydrate and fatty acid metabolism contribute to obesity-induced insulin resistance and/or T2D. Conversely, whether perturbations in… read more here.
Keywords: pathology; obesity; skeletal muscle; ketone body ... See more keywords
Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.733607
Abstract: Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, but there is still a lot to discover to comprehensively understand the underlying mechanisms. Autophagy is a key mechanism for… read more here.
Keywords: body metabolism; ketogenic diet; ketone body; autophagy ... See more keywords
Dysregulation of Ketone Body Metabolism Is Associated With Poor Prognosis for Clear Cell Renal Cell Carcinoma Patients
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01422
Abstract: Kidney is an important organ for ketone body metabolism. However, the role of abnormal ketone metabolism and its possible function in tumorigenesis of clear cell renal cell carcinoma (ccRCC) have not yet been elucidated. Three… read more here.
Keywords: ccrcc; metabolism; ketone body; body metabolism ... See more keywords