Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy.
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DOI: 10.1021/acs.orglett.2c00110
Abstract: A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acid is developed. Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on… read more here.
Keywords: ketone suzuki; ketone; coupling reaction; suzuki miyaura ... See more keywords