Synthesis of polysubstituted pyridazines via Cu-mediated C(sp3)-C(sp3) coupling/annulation of saturated ketones with acylhydrazones.
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DOI: 10.1039/d4cc02760d
Abstract: Pyridazine is a significant skeleton that widely exists in drugs and bioactive molecules. We herein describe expeditious approaches to access polysubstituted pyridazines from readily accessible unactivated ketones and acylhydrazones via Cu-promoted C(sp3)-C(sp3) coupling/cyclization sequences in… read more here.
Keywords: sp3; ketones acylhydrazones; sp3 coupling; sp3 sp3 ... See more keywords