A simple, direct synthesis of 3-vinylindoles from the carbocation-catalysed dehydrative cross-coupling of ketones and indoles. A combined experimental and computational study
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DOI: 10.1016/j.tet.2018.11.073
Abstract: Abstract A straightforward synthesis of a library of largely new 3-vinylindoles via a clean dehydrative coupling reaction between ketones and indoles has been developed. Highly stable, non-nucleophilic aryl(2-methylindol-3-yl)methylium salts have been used as efficient Lewis… read more here.
Keywords: simple direct; synthesis; synthesis vinylindoles; ketones indoles ... See more keywords