Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst
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DOI: 10.1039/d2ra07117g
Abstract: Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to… read more here.
Keywords: highly regioselective; lactams via; ketones ketoamides; cascade reaction ... See more keywords