Copper-Catalyzed 6-endo-dig Cyclization-Coupling of 2-Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water.
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DOI: 10.1021/acs.orglett.2c01654
Abstract: The cyclization-coupling reaction of 2-bromoaryl ketones and terminal alkynes is first realized by copper catalysis, which produces polyfunctional naphthyl aryl ethers in moderate to excellent yields with broad substrate scope and good functional group tolerance.… read more here.
Keywords: cyclization coupling; bromoaryl ketones; ketones terminal; endo dig ... See more keywords