Enantioselective metal-free reduction of ketones by a user-friendly silane with a reusable chiral additive
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DOI: 10.1016/j.tetlet.2018.06.032
Abstract: Abstract 1-Hydrosilatrane, a safe and easy-to-handle reducing reagent that can be inexpensively accessed, has been shown to reduce prochiral ketones asymmetrically in the presence of chiral 1,2-aminoalcohols with ees ranging from 8% to 86%. The… read more here.
Keywords: free reduction; enantioselective metal; reduction ketones; user friendly ... See more keywords