Mechanochemical Synthesis of Ketones via Chemoselective Suzuki-Miyaura Cross-Coupling of Acyl Chlorides.
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DOI: 10.1021/acs.orglett.2c00519
Abstract: The direct synthesis of ketones via acyl Suzuki-Miyaura cross-coupling of widely available acyl chlorides is a central transformation in organic synthesis. Herein, we report the first mechanochemical solvent-free method for highly chemoselective synthesis of ketones… read more here.
Keywords: synthesis ketones; suzuki miyaura; synthesis; ketones via ... See more keywords
Electrochemical Synthesis of β-Functionalized Ketones via Ring-Opening of Cycloalkanols.
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DOI: 10.1021/acs.orglett.2c01649
Abstract: The electrochemical deconstructive functionalization of cycloalkanols with nucleophiles has been studied, which allows functionalization to occur exclusively at the β-position of ketones. The substrate scope includes a wide range of cycloalkanols as well as diverse… read more here.
Keywords: electrochemical synthesis; synthesis functionalized; ketones via; functionalized ketones ... See more keywords
Synthesis of α-Alkenyl α,β-Unsaturated Ketones via Dehydrogermylation of Oxagermacycles with Regeneration of the Germanium(II) Species.
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DOI: 10.1021/acs.orglett.9b03454
Abstract: The synthesis of α-alkenyl α,β-unsaturated ketones using germanium(II) salts is reported. Oxagermacycles derived from α,β-unsaturated ketones with germanium(II) salts and aldehydes can be transformed into α-alkenyl α,β-unsaturated ketones. Ammonium salts promoted the elimination of Ge(II)… read more here.
Keywords: via dehydrogermylation; ketones via; germanium; unsaturated ketones ... See more keywords
Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones.
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DOI: 10.1039/c7cc04045h
Abstract: A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples)… read more here.
Keywords: ketones via; aromatic ketones; synthesis chiral; asymmetric hydrogenation ... See more keywords
C3-Arylation of indoles with aryl ketones via C-C/C-H activations.
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DOI: 10.1039/d1cc03954g
Abstract: C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good… read more here.
Keywords: ketones via; aryl ketones; arylation indoles; via activations ... See more keywords