Rational Exploration of Novel SDHI Fungicide through an Amide-β-ketonitrile Bioisosteric Replacement Strategy.
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DOI: 10.1021/acs.jafc.2c08606
Abstract: The identification of succinate dehydrogenase inhibitor (SDHI) fungicides bearing a novel scaffold is of great importance to control pathogenic fungi. Difluoromethyl-pyrazole β-ketonitrile derivatives were rationally designed through an innovative amide-β-ketonitrile bioisosteric replacement strategy and evaluated… read more here.
Keywords: sdhi; replacement strategy; ketonitrile bioisosteric; amide ketonitrile ... See more keywords