Palladium-catalyzed Cascade Reactions of δ-ketonitriles with Arylboronic Acids: Synthesis of Pyridines.
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DOI: 10.1021/acscombsci.9b00198
Abstract: This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry… read more here.
Keywords: cascade reactions; ketonitriles arylboronic; palladium catalyzed; arylboronic acids ... See more keywords