Ecotoxicological properties of ketoprofen and the S(+)-enantiomer (dexketoprofen): Bioassays in freshwater model species and biomarkers in fish PLHC-1 cell line.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3943
Abstract: The increased use of nonsteroidal anti-inflammatory drugs (NSAIDs) has resulted in their ubiquitous presence in the environment. The toxicological properties of these 2 widely prescribed NSAIDs, namely racemic ketoprofen and its enantiomer S(+)-ketoprofen (dexketoprofen), were… read more here.
Keywords: dexketoprofen; ketoprofen enantiomer; cell line; ketoprofen dexketoprofen ... See more keywords
Targeted eco-pharmacovigilance for ketoprofen in the environment: Need, strategy and challenge.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.12.020
Abstract: Implementing "targeted" eco-pharmacovigilance(EPV) which focuses on individual or specific pharmaceuticals on a prioritised basis is a feasible, economical and customized approach to reduce the environmental concentrations and risks of pharmaceuticals. Non-steroidal anti-inflammatory drugs(NSAIDs) remaining in… read more here.
Keywords: targeted epv; targeted eco; eco pharmacovigilance; ketoprofen ... See more keywords
Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.002
Abstract: The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4+, 8+… read more here.
Keywords: dendrimer; permeation; drug; ketoprofen ... See more keywords
Enantioselective analysis of ketoprofen in human saliva by liquid chromatography/tandem mass spectrometry with chiral derivatization
Sign Up to like & getrecommendations! Published in 2018 at "Microchemical Journal"
DOI: 10.1016/j.microc.2018.08.025
Abstract: Abstract The enantioselective analytical method for trace ketoprofen (KET) in human saliva was developed for the first time using liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) combined with a derivatization using a chiral reagent, (S)‑1‑methyl‑4‑(5‑(3‑aminopyrrolidin‑1‑yl)‑2,4‑dinitro‑phenyl)piperazine (APy‑PPZ).… read more here.
Keywords: mass spectrometry; human saliva; liquid chromatography; ketoprofen ... See more keywords
A new crystalline ketoprofen sodium salt: solid-state characterization, solubility, and stability.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2021.11.011
Abstract: Ketoprofen (KTP) is an Active Pharmaceutical Ingredient (API) that has low solubility in aqueous solvents. The use of KTP salts has attracted attention due to its improvements in terms of solubility, tolerability, higher rate and… read more here.
Keywords: sodium salt; ktp; solubility; ketoprofen ... See more keywords
Ketoprofen-induced inhibition of symptoms of behavioural fever observed in wintering Planorbarius corneus (L.) (Gastropoda: Planorbidae)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molluscan Studies"
DOI: 10.1093/mollus/eyx026
Abstract: Research on behavioural fever in Planorbarius corneus was undertaken using a longitudinal thermal gradient. Before the experiment, snails were acclimated at 19 °C. Following injections of lipopolysaccharide (LPS, a pyrogenic agent), ketoprofen (an antipyretic) or… read more here.
Keywords: planorbarius corneus; behavioural fever; symptoms behavioural; ketoprofen ... See more keywords
Ketoprofen‐induced photoallergic consort contact dermatitis: A difficult diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Contact Dermatitis"
DOI: 10.1111/cod.14058
Abstract: Consort contact dermatitis is an allergic or photoallergic dermatitis caused by sensitizers conveyed by a partner or companion via direct interpersonal skin contact or indirect contact through shared objects. We describe a patient who experienced… read more here.
Keywords: contact; contact dermatitis; ketoprofen; consort contact ... See more keywords
Ketoprofen-FA Co-crystal: In Vitro and In Vivo Investigation for the Solubility Enhancement of Drug by Design of Expert.
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02253-5
Abstract: The present piece of research work is framed for improving the solubility of ketoprofen by forming co-crystal using fumaric acid as a coformer. Co-crystal of ketoprofen and fumaric acid was prepared by simple solvent-assisted grinding… read more here.
Keywords: crystal; vitro vivo; ketoprofen; drug ... See more keywords
An evaluation of ketoprofen as an intranasal anti-inflammatory agent.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202212_30474
Abstract: OBJECTIVE The objective of the study was to evaluate the effect of ketoprofen when locally applied to tissue-cultured nasal epithelium. MATERIALS AND METHODS Healthy primary nasal epithelial cells were grown in a tissue culture medium.… read more here.
Keywords: ketoprofen; evaluation ketoprofen; ketoprofen intranasal; nasal epithelial ... See more keywords
Photoinduced Oxidation of Lipid Membranes in the Presence of the Nonsteroidal Anti-Inflammatory Drug Ketoprofen
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12030251
Abstract: The damage of cell membranes induced by photosensitive drugs has attracted the significant attention of researchers in various fields of medicine. Ketoprofen (KP) is known to be the most photosensitive among the nonsteroidal anti-inflammatory drugs.… read more here.
Keywords: lipid membranes; oxidation; ketoprofen; nonsteroidal anti ... See more keywords
Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030378
Abstract: Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue. However, ketoprofen has a low solubility; therefore, it is essential… read more here.
Keywords: ketoprofen; pva pvp; dissolving microneedles; nanosuspension grinding ... See more keywords