Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives.
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DOI: 10.1021/acs.orglett.2c01378
Abstract: The desymmetrization of a prochiral 6-oxaspiro[3.3]heptane-2-carboxylic acid derivative via biocatalytic ketoreductase-mediated reduction has provided access to both enantiomers in high ee. The axially chiral alcohol was converted to the corresponding ester alcohol, amino acid, and… read more here.
Keywords: ketoreductase catalyzed; catalyzed access; heptane; axially chiral ... See more keywords