Molecular modelling approaches predicted 1,2,3-triazolyl ester of ketorolac (15K) to be a novel allosteric modulator of the oncogenic kinase PAK1
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DOI: 10.1038/s41598-021-96817-3
Abstract: P21-activated kinases (PAKs) are serine/threonine protein kinase which have six different isoforms (PAK1–6). Of those, PAK1 is overexpressed in many cancers and considered to be a major chemotherapeutic target. Most of the developed PAK1 inhibitor… read more here.
Keywords: novel allosteric; inhibitor; ester ketorolac; triazolyl ester ... See more keywords