The Ketosynthase Domain Constrains the Design of Polyketide Synthases.
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DOI: 10.1021/acschembio.0c00405
Abstract: Modular polyketide synthases (PKSs) produce complex, bioactive secondary metabolites in assembly line-like multistep reactions. Longstanding efforts to produce novel, biologically active compounds by recombining intact modules to new modular PKSs have mostly resulted in poorly… read more here.
Keywords: modular pkss; domain; polyketide synthases; pkss ... See more keywords