Abstract 3221: Kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies
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DOI: 10.1158/1538-7445.am2017-3221
Abstract: Ovarian cancer (OC) is a molecularly and histologically heterogeneous disease; however, standard treatment is the same for all subtypes. High-grade serous OC initially responds to chemotherapy; however, low-grade serous and clear cell OC are relatively… read more here.
Keywords: cell lines; kevetrin; ovarian cancer; p53 ... See more keywords
Abstract 1650: Discovery of a novel Kevetrin analog as a potential therapeutic for ovarian cancer
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DOI: 10.1158/1538-7445.am2023-1650
Abstract: Kevetrin is an investigational new drug in phase I clinical trial on solid tumors (NCT01664000). It has shown its efficacy in various tumors, including lung, breast, colon, and ovarian cancer cell and xenograft models, both… read more here.
Keywords: cell; ovarian cancer; compound 900; kevetrin ... See more keywords