Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.02.007
Abstract: Tumor-promoting inflammation and avoiding immune destruction are hallmarks of cancer. Here, we demonstrate that the pro-inflammatory cytokine interleukin (IL)-18 is critically involved in these hallmarks in multiple myeloma (MM). Mice deficient for IL-18 were remarkably… read more here.
Keywords: microenvironment; key driver; multiple myeloma; dysregulated key ... See more keywords
Survey Key Driver Analysis: Perhaps the Right Question Is, “Are We There Yet?”
Sign Up to like & getrecommendations! Published in 2017 at "Industrial and Organizational Psychology"
DOI: 10.1017/iop.2017.20
Abstract: In their focal article, Cucina, Walmsley, Gast, Martin, and Curtin (2017) raise an important and timely issue, but go too far in arguing that practitioners should abandon survey key driver analysis (SKDA) altogether. There are… read more here.
Keywords: driver analysis; survey key; key driver; question yet ... See more keywords
Fire as a key driver of Earth's biodiversity
Sign Up to like & getrecommendations! Published in 2019 at "Biological Reviews"
DOI: 10.1111/brv.12544
Abstract: Many terrestrial ecosystems are fire prone, such that their composition and structure are largely due to their fire regime. Regions subject to regular fire have exceptionally high levels of species richness and endemism, and fire… read more here.
Keywords: fire key; key driver; fire prone; biodiversity ... See more keywords
Sex-Stratified Gene Regulatory Networks Reveal Female Key-Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching.
Sign Up to like & getrecommendations! Published in 2021 at "Circulation"
DOI: 10.1161/circulationaha.120.051231
Abstract: Background: While sex differences in coronary artery disease (CAD) are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology of such differences remains largely unknown. In CAD, recent integrative systems biological… read more here.
Keywords: regulatory networks; cell; sex differences; sex ... See more keywords
A Novel Transcriptome Integrated Network Approach Identifies the Key Driver lncRNA Involved in Cell Cycle With Chromium (VI)-Treated BEAS-2B Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.597803
Abstract: Hexavalent chromium [Cr(VI)] is a well-known occupational carcinogen, but the mechanisms contributing to DNA damage and cell cycle alternation have not been fully characterized. To study the dose-response effects of Cr(VI) on transcription, we exposed… read more here.
Keywords: beas cells; network; cell cycle; key driver ... See more keywords
Myelin lipid deficiency: a new key driver of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.343893
Abstract: Lipids play essential biological functions that include acting as components of biological membranes, energy storage, signaling, nutrients, transporters, enzyme activators, among others. Compared with the multiple research methods to assess DNA, RNA, and protein content,… read more here.
Keywords: myelin lipid; key driver; driver alzheimer; deficiency new ... See more keywords