PYCR, a key enzyme in proline metabolism, functions in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03047-y
Abstract: Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth… read more here.
Keywords: key enzyme; enzyme proline; pycr key; proline metabolism ... See more keywords
Crystal structure of p-nitrophenol 4-monooxygenase PnpA from Pseudomonas putida DLL-E4: The key enzyme involved in p-nitrophenol degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.040
Abstract: p-Nitrophenol 4-monooxygenase PnpA, the key enzyme in the hydroquinone pathway of p-nitrophenol (PNP) degradation, catalyzes the monooxygenase reaction of PNP to p-benzoquinone in the presence of FAD and NADH. Here, we determined the first crystal… read more here.
Keywords: key enzyme; crystal structure; monooxygenase pnpa; nitrophenol monooxygenase ... See more keywords
Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.10.001
Abstract: ABSTRACT Chondroitin sulfate (CS) is a sulfated glycosaminoglycan composed of a long chain of repeating disaccharide units that are attached to core proteins, resulting in CS proteoglycans (CSPGs). In the mature brain, CS is concentrated… read more here.
Keywords: key enzyme; regeneration; roles csgalnact1; csgalnact1 key ... See more keywords
Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02654
Abstract: The biosynthetic pathway of brassicicenes, derived from the phytopathogen Pseudocercospora fijiensis, was fully reconstituted. Heterologous expression of the eight genes highly expressed in infected leaf tissues generated a new brassicicene derivative as a final product.… read more here.
Keywords: key enzyme; total biosynthesis; identification key; brassicicenes identification ... See more keywords
Insights into the catalytic and regulatory mechanisms of dihydroflavonol 4-reductase, a key enzyme of anthocyanin synthesis in Zanthoxylum bungeanum.
Sign Up to like & getrecommendations! Published in 2022 at "Tree physiology"
DOI: 10.1093/treephys/tpac101
Abstract: Accumulation of anthocyanins largely determines the fruit color, and dihydroflavonol 4-reductase (DFR) is a key enzyme in the formation of anthocyanins. However, the catalytic and regulatory mechanisms of DFR are unclear. In this study, the… read more here.
Keywords: zanthoxylum bungeanum; dihydroflavonol reductase; activity; key enzyme ... See more keywords
Crystal structure of a key enzyme for anaerobic ethane activation
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abg1765
Abstract: How to feed an enzyme ethane When released from ocean floor seeps, small hydrocarbons are rapidly consumed by micro-organisms. Methane is highly abundant and is both produced and consumed by microbes through well understood biochemical… read more here.
Keywords: key enzyme; ethane; crystal structure; structure key ... See more keywords