Efficient synthesis of 3,4-diarylpyrrole-2-carboxylates, the key fragments of natural antimitotic agents
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2375-1
Abstract: Barton-Zard reaction of nitrostilbenes with ethyl isocyanoacetate carried out in EtOH in the presence of K2CO3 allowed us to minimize the formation of side products and to obtain 3,4-diarylpyrrole-2-carboxylates in high yields. read more here.
Keywords: fragments natural; carboxylates key; synthesis diarylpyrrole; efficient synthesis ... See more keywords
Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00090
Abstract: A concise route toward two advanced fragments in the context of the total synthesis of the unique natural product azamerone is reported. Key synthetic features include the enantioselective synthesis of an epoxysilane and its Lewis-acid-induced… read more here.
Keywords: azamerone; synthesis two; key fragments; fragments complex ... See more keywords