Overexpression of the key genes in the biosynthetic pathways of lipid A and peptidoglycan in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2364
Abstract: Gram‐negative bacterium Escherichia coli has a tripartite cell envelope with a cytoplasmic membrane, a peptidoglycan layer, and an asymmetric outer membrane containing lipopolysaccharide in its outer leaflet. The biogenesis of peptidoglycan and lipopolysaccharide shares the… read more here.
Keywords: cell; key genes; escherichia coli; overexpression ... See more keywords
Identification of key genes and upstream regulators in ischemic stroke
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1319
Abstract: Ischemic stroke (IS) causes severe neurological impairments and physical disabilities and has a high economic burden. Our study aims to identify the key genes and upstream regulators in IS by integrated microarray analysis. read more here.
Keywords: regulators ischemic; ischemic stroke; identification key; genes upstream ... See more keywords
Integrated analysis and network pharmacology approaches to explore key genes of Xingnaojing for treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1610
Abstract: Alzheimer's disease (AD), as a neurodegenerative condition, is one of the leading causes of dementia. Our study aims to explore the key genes of Xingnaojing (XNJ) for treatment of AD by integrated microarray analysis and… read more here.
Keywords: alzheimer disease; explore key; key genes; pharmacology ... See more keywords
Identification of key genes associated with secondary metabolites biosynthesis by system network analysis in Valeriana officinalis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of plant research"
DOI: 10.1007/s10265-021-01277-5
Abstract: Valeriana officinalis is a medicinal plant, a source of bioactive chemical compounds and secondary metabolites which are applied in pharmaceutical industries. The advent of ethnomedicine has provided alternatives for disease treatment and has increased demands… read more here.
Keywords: metabolic pathways; valeriana officinalis; key genes; secondary metabolites ... See more keywords
Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea
Sign Up to like & getrecommendations! Published in 2018 at "Sleep and Breathing"
DOI: 10.1007/s11325-018-1694-7
Abstract: PurposeObstructive sleep apnea (OSA) is induced by obstruction of the upper airway, which can raise multiple health risks. This study is designed to reveal the key genes involved in OSA.MethodsGSE38792 was extracted from Gene Expression… read more here.
Keywords: network; analysis; key genes; sleep ... See more keywords
Identification of key genes and construction of microRNA–mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2216-2
Abstract: Multiple myeloma (MM) is a common hematological malignancy. To identify key genes and microRNAs in MM, we downloaded two gene expression profiles (GSE16558 and GSE47552) and two microRNA expression profiles (GSE17498 and GSE16558) from the… read more here.
Keywords: multiple myeloma; key genes; signaling pathway; microrna mrna ... See more keywords
Identifying key genes associated with Hirschsprung’s disease based on bioinformatics analysis of RNA-sequencing data
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Pediatrics"
DOI: 10.1007/s12519-017-0002-0
Abstract: BackgroundHirschsprung’s disease (HSCR) is a type of megacolon induced by deficiency or dysfunction of ganglion cells in the distal intestine and is associated with developmental disorders of the enteric nervous system. To explore the mechanisms… read more here.
Keywords: sequencing data; analysis; disease; key genes ... See more keywords
Bioinformatics Analysis and Identification of Genes and Molecular Pathways Involved in Venous Thromboembolism (VTE).
Sign Up to like & getrecommendations! Published in 2021 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2021.02.020
Abstract: OBJECTIVES To explore the key genes, and correlated pathways in venous thromboembolism (VTE) via bioinformatic analysis, and expected our findings could contribute to the development of new biomarkers and therapeutic target for VTE. METHODS Two… read more here.
Keywords: key genes; analysis; venous thromboembolism; thromboembolism vte ... See more keywords
Identification of MDM2, YTHDF2 and DDX21 as potential biomarkers and targets for treatment of type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.019
Abstract: Type 2 diabetes (T2D) is a multifactorial and polygenetic disease, although its exact etiology remains poorly understood. The objective of this study was to identify key biomarkers and potential molecular mechanisms in the development of… read more here.
Keywords: analysis; ythdf2 ddx21; potential biomarkers; key genes ... See more keywords
Identification of key genes and construction of CircRNA–miRNA–mRNA regulatory networks in osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Electronic Journal of Biotechnology"
DOI: 10.1016/j.ejbt.2018.11.004
Abstract: Background: Osteoarthritis (OA) is one of the most frequent degenerative joint diseases with high rate of disability, but its mode of action remains largely unclear. The current study was aimed at identifying key genes and… read more here.
Keywords: circrna mirna; regulatory networks; mrna regulatory; signaling pathway ... See more keywords
Identification of key genes in Ankylosing spondylitis.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.03.016
Abstract: Ankylosing spondylitis (AS) is a common form of seronegative spondyloarthritis. We had identified differentially expressed genes (DEGs) in AS based on our previous RNA-sequencing results. Our study aimed to identify key genes in AS by… read more here.
Keywords: ankylosing spondylitis; identification key; key genes; integrated analysis ... See more keywords