Preparation, Characterization and Crystal Structures of a Key Intermediate, and a Significant Impurity, in the Synthesis of Repaglinide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Crystallography"
DOI: 10.1007/s10870-019-00811-7
Abstract: Abstract The crystal structure of 2-(3-ethoxy-4-(methoxycarbonyl)phenyl) acetic acid ( RGA ), an important intermediate in the preparation of Repaglinide, has been carried out. Hydrogen bonds between the carboxylate groups link the molecules into dimers while… read more here.
Keywords: key intermediate; crystal structures; impurity; preparation characterization ... See more keywords
Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Papers"
DOI: 10.1007/s11696-019-00826-6
Abstract: The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An… read more here.
Keywords: preparing coenzyme; efficient synthesis; key intermediate; intermediate preparing ... See more keywords
HPLC and GC methods development for the analysis of key intermediate for synthesis of dicamba
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2020.09.046
Abstract: Abstract The microreactor based hydroxylation process of 1,2,4-trichlorobezene for producing 2,5-dichlorphenol, the key intermediate of dicamba, is energy efficient and cost effective. But the 2,5-dicholorphneol is present in a mixed state after production. The reaction… read more here.
Keywords: dichlorophenol; hplc; key intermediate; analysis ... See more keywords
Accessing a key intermediate for sub(oxa)porphyrins from a sustainable raw-material—Cashew apple bagasse
Sign Up to like & getrecommendations! Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.113081
Abstract: Abstract Furan-2,5-diylbis(phenylmethanol) is a key intermediate to access sub(oxa)porphyrins. Previously, this key intermediate was accessible from fossil-derived furan using highly dangerous lithium reagents. Presently, we have produced this key intermediate from cashew apple bagasse (CAB),… read more here.
Keywords: key intermediate; cab; oxa porphyrins; sub oxa ... See more keywords
Industrial landmarks in the development of sustainable production processes for the β-lactam antibiotic key intermediate 7-aminocephalosporanic acid (7-ACA)
Sign Up to like & getrecommendations! Published in 2017 at "Sustainable Chemistry and Pharmacy"
DOI: 10.1016/j.scp.2016.08.001
Abstract: Abstract Reflecting its importance as key intermediate for the large scale manufacture of β-lactam-type antibiotic drugs being widely used in antibacterial therapy, tremendous achievements have been made over the past decades in developing both, economically… read more here.
Keywords: production; key intermediate; chemistry; aminocephalosporanic acid ... See more keywords
Scalable synthesis of a tetrasubstituted 7-azabenzofuran as a key intermediate for a class of potent HCV NS5B inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131642
Abstract: Abstract A series of tetrasubstituted 7-azabenzofurans displays remarkable pan-genotype inhibition of HCV NS5B polymerase. One of them has been identified as a potential clinical candidate. Completely different from the original synthesis of a common and… read more here.
Keywords: hcv ns5b; key intermediate; intermediate class; synthesis ... See more keywords
Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib
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DOI: 10.1021/acsomega.1c06920.s001
Abstract: Olaparib (Lynparza) is a potent, highly selective inhibitor of poly(ADP-ribose)polymerase enzymes, approved by the U.S. FDA and EMA for the treatment of ovarian cancer. Herein, we report a practical, economical, and scalable process for the… read more here.
Keywords: poly adp; adp ribose; inhibitor; ribose polymerase ... See more keywords
Practical Synthesis of 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid—Key Intermediate of Lifitegrast (Xiidra)
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DOI: 10.1021/acsomega.3c02188
Abstract: In the present study, a practical method for synthesizing the key intermediate 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1) of Lifitegrast was proposed. First, an investigation was conducted into the utilization of the impurity and recrystallization method in the… read more here.
Keywords: dichlorotetrahydroisoquinoline; carboxylic acid; synthesis; lifitegrast ... See more keywords
Spectroscopic evidence for 1,2-diiminoethane - a key intermediate in imidazole synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03065a
Abstract: Simple imines and diimines are common building blocks in organic synthesis, but the compound class is spectroscopically not well characterized. Herein we report the formation of the simplest diimine, namely 1,2-diiminoethane, as well as spectroscopic… read more here.
Keywords: spectroscopy; diiminoethane key; synthesis; evidence diiminoethane ... See more keywords
Small change for big improvement in the preparation of the key intermediate N1, N3-disubstituted 1,3,5-triazone of ensitrelvir
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07844a
Abstract: In this study, the key intermediate N1, N3-disubstituted 1,3,5-triazone of ensitrelvir fumaric acid, approved in Japan for the treatment of SARS-CoV-2 infection under the emergency regulatory approval system, was produced from S-ethylisothiourea hydrobromide and aminomethyl… read more here.
Keywords: intermediate disubstituted; ensitrelvir; triazone ensitrelvir; disubstituted triazone ... See more keywords
2,2,2-Trifluoro-N-(1-iminoethyl)-N′ arylacetimidamides as key intermediate for synthesis of trifluoromethyl 1,2,4-triazoles
Sign Up to like & getrecommendations! Published in 2023 at "Synthetic Communications"
DOI: 10.1080/00397911.2023.2204193
Abstract: Abstract An I2-mediated N–N coupling reaction has been described for oxidation cyclization of 2,2,2-trifluoro-N-(1-iminoethyl)-N′-arylacetimidamide to synthesis of novel 3-methyl-1-aryl-5-(trifluoromethyl)-1H-1,2,4-triazole derivatives under mild conditions with excellent yield without need to any purification. This procedure doesn’t have… read more here.
Keywords: iminoethyl arylacetimidamides; arylacetimidamides key; trifluoro iminoethyl; synthesis ... See more keywords