BINOL-3,3'-Dicarboxylic Acid: Resolution for the Key Intermediate of (S)-bepotastine.
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DOI: 10.1002/chir.70056
Abstract: (S)-Bepotastine is a highly selective histamine H1-receptor antagonist in the treatment of allergic rhinitis and other allergic diseases. We achieved a facile and convenient synthesis of (S)-bepotastine by resolving an early stage synthetic precursor. We… read more here.
Keywords: resolution key; acid resolution; binol dicarboxylic; key intermediate ... See more keywords
Preparation, Characterization and Crystal Structures of a Key Intermediate, and a Significant Impurity, in the Synthesis of Repaglinide
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DOI: 10.1007/s10870-019-00811-7
Abstract: Abstract The crystal structure of 2-(3-ethoxy-4-(methoxycarbonyl)phenyl) acetic acid ( RGA ), an important intermediate in the preparation of Repaglinide, has been carried out. Hydrogen bonds between the carboxylate groups link the molecules into dimers while… read more here.
Keywords: key intermediate; crystal structures; impurity; preparation characterization ... See more keywords
Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q
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DOI: 10.1007/s11696-019-00826-6
Abstract: The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An… read more here.
Keywords: preparing coenzyme; efficient synthesis; key intermediate; intermediate preparing ... See more keywords
HPLC and GC methods development for the analysis of key intermediate for synthesis of dicamba
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2020.09.046
Abstract: Abstract The microreactor based hydroxylation process of 1,2,4-trichlorobezene for producing 2,5-dichlorphenol, the key intermediate of dicamba, is energy efficient and cost effective. But the 2,5-dicholorphneol is present in a mixed state after production. The reaction… read more here.
Keywords: dichlorophenol; hplc; key intermediate; analysis ... See more keywords
Accessing a key intermediate for sub(oxa)porphyrins from a sustainable raw-material—Cashew apple bagasse
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DOI: 10.1016/j.indcrop.2020.113081
Abstract: Abstract Furan-2,5-diylbis(phenylmethanol) is a key intermediate to access sub(oxa)porphyrins. Previously, this key intermediate was accessible from fossil-derived furan using highly dangerous lithium reagents. Presently, we have produced this key intermediate from cashew apple bagasse (CAB),… read more here.
Keywords: key intermediate; cab; oxa porphyrins; sub oxa ... See more keywords
Industrial landmarks in the development of sustainable production processes for the β-lactam antibiotic key intermediate 7-aminocephalosporanic acid (7-ACA)
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DOI: 10.1016/j.scp.2016.08.001
Abstract: Abstract Reflecting its importance as key intermediate for the large scale manufacture of β-lactam-type antibiotic drugs being widely used in antibacterial therapy, tremendous achievements have been made over the past decades in developing both, economically… read more here.
Keywords: production; key intermediate; chemistry; aminocephalosporanic acid ... See more keywords
Scalable synthesis of a tetrasubstituted 7-azabenzofuran as a key intermediate for a class of potent HCV NS5B inhibitors
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DOI: 10.1016/j.tet.2020.131642
Abstract: Abstract A series of tetrasubstituted 7-azabenzofurans displays remarkable pan-genotype inhibition of HCV NS5B polymerase. One of them has been identified as a potential clinical candidate. Completely different from the original synthesis of a common and… read more here.
Keywords: hcv ns5b; key intermediate; intermediate class; synthesis ... See more keywords
Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib
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DOI: 10.1021/acsomega.1c06920.s001
Abstract: Olaparib (Lynparza) is a potent, highly selective inhibitor of poly(ADP-ribose)polymerase enzymes, approved by the U.S. FDA and EMA for the treatment of ovarian cancer. Herein, we report a practical, economical, and scalable process for the… read more here.
Keywords: poly adp; adp ribose; inhibitor; ribose polymerase ... See more keywords
Practical Synthesis of 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid—Key Intermediate of Lifitegrast (Xiidra)
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DOI: 10.1021/acsomega.3c02188
Abstract: In the present study, a practical method for synthesizing the key intermediate 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1) of Lifitegrast was proposed. First, an investigation was conducted into the utilization of the impurity and recrystallization method in the… read more here.
Keywords: dichlorotetrahydroisoquinoline; carboxylic acid; synthesis; lifitegrast ... See more keywords
Photochemical Generation and Characterization of Alanine Imine: A Key Intermediate in Prebiotic Amino Acid Formation.
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DOI: 10.1021/jacs.5c14327
Abstract: Simple imino acids have received sparse consideration as reactive intermediates in the formation of amino acids under prebiotic or astrochemical conditions. Under cryogenic matrix isolation conditions, 2-azidopropionic acid decomposes after ultraviolet (UV) irradiation to dinitrogen… read more here.
Keywords: spectroscopy; key intermediate; alanine imine; amino acid ... See more keywords
Infrared and ultraviolet spectroscopic characterization of a key intermediate during DNA repair by (6-4) photolyase
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DOI: 10.1038/s42004-025-01625-9
Abstract: Ultraviolet (UV) irradiation of DNA causes genotoxic photolesions, such as carcinogenic pyrimidine(6-4)pyrimidone photoproducts ((6-4)PPs). In many organisms, (6-4)PPs are repaired by (6-4) photolyases, which contain a flavin chromophore and use blue light energy to initiate… read more here.
Keywords: spectroscopic; key intermediate; repair; dna repair ... See more keywords