The role of chirality in a set of key intermediates of pharmaceutical interest, 3‐aryl‐substituted‐&ggr;‐butyrolactones, evidenced by chiral HPLC separation and by chiroptical spectroscopies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.01.007
Abstract: HIGHLIGHTSHPLC Separation of enantiomers of four 3‐aryl‐substituted‐&ggr;‐butyrolactones (3AGBL).ECD, ORD, and VCD of four 3AGBL. Similarity indexes calculated for VCD and ECD.From AD‐H columns (S) enantiomers of 3AGBL elute before (R) enantiomers.Molecular Docking explains elution order.Lactone‐chirality… read more here.
Keywords: substituted ggr; pharmaceutical interest; aryl substituted; key intermediates ... See more keywords
Iron(II) Bis(acetylide) Complexes as Key Intermediates in the Catalytic Hydrofunctionalization of Terminal Alkynes
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DOI: 10.1021/acscatal.8b01942
Abstract: Nonclassical iron(II) polyhydride complexes supported by PNP-pincer ligands were found to be very active catalysts for the Z-selective hydroboration and head-to-head dimerization of terminal alkynes. Iron(II) bis(acetylide) complexes are identified as catalytically active species in… read more here.
Keywords: iron bis; key intermediates; terminal alkynes; alkynes iron ... See more keywords
Snapshots of key intermediates unveiling the growth from silver ions to Ag70 nanoclusters
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DOI: 10.1039/d2sc04204e
Abstract: Nanoclusters (NCs) are considered as initial states of condensed matter, and unveiling their formation mechanism is of great importance for directional synthesis of nanomaterials. Here, we initiate the reaction of Ag(i) ions under weak reducing… read more here.
Keywords: snapshots key; growth; key intermediates; silver ... See more keywords
Identifying key intermediates generated in situ from Cu(II) salt–catalyzed C–H functionalization of aromatic amines under illumination
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DOI: 10.1126/sciadv.1700666
Abstract: Cu(II) salts can activate C–H bonds of aromatic amines or imines to construct C–C bonds in air without external photosensitizer. Copper compounds involved in photocatalysis have recently spurred considerable interest for their novel transformations. However,… read more here.
Keywords: key intermediates; aromatic amines; salt catalyzed; catalyzed functionalization ... See more keywords