Articles with "key mediator" as a keyword



Photo by bermixstudio from unsplash

CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.

Sign Up to like & get
recommendations!
Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-06-791103

Abstract: To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2] These patients have an increased… read more here.

Keywords: ptpn11; ccl3 key; activating mutations; key mediator ... See more keywords