Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451233
Abstract: Autoimmune diseases encompass a range of conditions in which our own immune system reacts against molecules encoded by our own genome. This phenomenon is mediated by the action of antigen receptors expressed by T and… read more here.
Keywords: key players; single cell; narrowing key; players autoimmunity ... See more keywords
Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key Players and PINK1/PARKIN Mediated Mitophagy in an Experimental Parkinson's Rat Model
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70607
Abstract: Parkinson's disease (PD) is the fastest growing neurodegenerative disorder worldwide. Available treatments are only symptomatic, urging the demand for new therapies. Ferroptosis is increasingly reported as a critical player in neurodegeneration. Meanwhile, ferroptosis is activated… read more here.
Keywords: key players; ferroptosis; mitophagy; ferroptosis mitophagy ... See more keywords
Proprotein convertases: Key players in inflammation-related malignancies and metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Letters"
DOI: 10.1016/j.canlet.2019.12.027
Abstract: Abstract Many cancers occur from locations of inflammation due to chronic irritation and/or infection. Tumor microenvironment contains various different inflammatory cells and mediators that orchestrate diverse neoplastic processes, including proliferation, survival, adhesion and migration. In… read more here.
Keywords: key players; convertases key; inflammatory cells; proprotein convertases ... See more keywords
Gut macrophages: key players in intestinal immunity and tissue physiology.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.11.011
Abstract: The mammalian gastrointestinal tract harbors a large reservoir of tissue macrophages, which, in concert with other immune cells, help to maintain a delicate balance between tolerance to commensal microbes and food antigens, and resistance to… read more here.
Keywords: key players; players intestinal; tissue; physiology ... See more keywords
On the role of key players in rural social innovation processes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Rural Studies"
DOI: 10.1016/j.jrurstud.2021.04.010
Abstract: Abstract Social innovation (SI) research tends to understand rural SI processes as collective initiatives of equally engaged, supportive, and like-minded people. However, recent research has indicated that SI projects often benefit from dedicated key players… read more here.
Keywords: key players; social innovation; players rural; rural processes ... See more keywords
Plant Hormones: Key Players in Gut Microbiota and Human Diseases?
Sign Up to like & getrecommendations! Published in 2017 at "Trends in plant science"
DOI: 10.1016/j.tplants.2017.07.003
Abstract: It is well established that plant hormones such as auxins, cytokinins (CKs), and abscisic acid (ABA) not only govern important plant physiological traits but are key players in plant-microbe interactions. A poorly appreciated fact, however,… read more here.
Keywords: key players; plant hormones; hormones key; plant ... See more keywords
Improving Identification of Key Players in Aging via Network De-Noising and Core Inference
Sign Up to like & getrecommendations! Published in 2017 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2015.2495170
Abstract: Current “ground truth” knowledge about human aging has been obtained by transferring aging-related knowledge from well-studied model species via sequence homology or by studying human gene expression data. Since proteins function by interacting with each… read more here.
Keywords: key players; network; noising core; network noising ... See more keywords
1‐Deoxyceramides – Key players in lipotoxicity and progression to type 2 diabetes?
Sign Up to like & getrecommendations! Published in 2021 at "Acta Physiologica"
DOI: 10.1111/apha.13635
Abstract: Ceramides are bioactive sphingolipids, comprised of sphingosine and a fatty acyl chain. They have been recognized as key mediators of lipotoxicity; a phenomenon where excess fat in adipose tissue leads to de novo synthesis of… read more here.
Keywords: key players; players lipotoxicity; lipotoxicity progression; type diabetes ... See more keywords
Macrophage nuclear receptors: Emerging key players in infectious diseases
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007585
Abstract: Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. For decades, NRs have been therapeutic targets because their activity can be pharmacologically modulated by specific ligands and… read more here.
Keywords: key players; nuclear receptors; infectious diseases; receptors emerging ... See more keywords
Macrophages as Emerging Key Players in Mitochondrial Transfers
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.747377
Abstract: Macrophages are a group of heterogeneous cells widely present throughout the body. Under the influence of their specific environments, via both contact and noncontact signals, macrophages integrate into host tissues and contribute to their development… read more here.
Keywords: transfers macrophages; key players; mitochondrial transfers; players mitochondrial ... See more keywords
The forgotten key players in rheumatoid arthritis: IL-8 and IL-17 – Unmet needs and therapeutic perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.956127
Abstract: Despite the relevant advances in our understanding of the pathogenetic mechanisms regulating inflammation in rheumatoid arthritis (RA) and the development of effective therapeutics, to date, there is still a proportion of patients with RA who… read more here.
Keywords: forgotten key; extra articular; rheumatoid arthritis; synovial membrane ... See more keywords