Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21886
Abstract: The key proteins involved in transcriptional regulation play convergent roles in cellular homeostasis, and their dysfunction mediates aberrant gene expressions that underline the hallmarks of tumorigenesis. As tumor progression is dependent on such abnormal regulation… read more here.
Keywords: targeting key; involved transcriptional; transcriptional regulation; regulation ... See more keywords
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96750-5
Abstract: Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial… read more here.
Keywords: wound healing; identification key; healing cancer; cancer ... See more keywords
Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression.
Sign Up to like & getrecommendations! Published in 2025 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000003645
Abstract: BACKGROUND Cytopathology cannot be used to reliably distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC), the second most common form of thyroid cancer, because they exhibit nearly identical cellular morphology. Given the challenges… read more here.
Keywords: progression; follicular thyroid; thyroid cancer; thyroid ... See more keywords
Comparative proteomic analysis provides insight into the key proteins as potential targets underlying the effect of malachite green against Ichthyophthirius multifiliis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of fish diseases"
DOI: 10.1111/jfd.13346
Abstract: Target identification is important for drug discovery. Unfortunately, no drug targets have been found in Ichthyophthirius multifiliis until now and further limited development of the novel drug for Ichthyophthiriasis. In this study, an iTRAQ-based quantitative… read more here.
Keywords: malachite green; potential targets; proteomic analysis; ichthyophthirius multifiliis ... See more keywords
Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/6181943
Abstract: Background Insomnia is a sleep disorder and the cause of many healthy problems. However, there are few studies on patients with insomnia and dreaminess at present. Therefore, this study is aimed at exploring the pathological… read more here.
Keywords: insomnia patients; ppi network; patients dreams; reveals molecular ... See more keywords
Identification of key proteins in early-onset Alzheimer’s disease based on WGCNA
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2024.1412222
Abstract: Introduction Early-onset Alzheimer’s disease (EOAD) is sporadic, highly heterogeneous, and its underlying pathogenic mechanisms remain largely elusive. Proteomics research aims to uncover the biological processes and key proteins involved in disease progression. However, no proteomic… read more here.
Keywords: alzheimer disease; pathology; early onset; expression ... See more keywords
Nuclear Lamins: Key Proteins for Embryonic Development
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020198
Abstract: Simple Summary The biology of a multicellular organism is extremely complex, leaving behind a realm of compound yet systematic mechanisms still to be unraveled. The nucleus is a vital cellular organelle adapted to storing and… read more here.
Keywords: nuclear lamins; development; lamins key; proteins embryonic ... See more keywords
Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050690
Abstract: Coronavirus disease 2019 (COVID-19) is still an active global public health issue. Although vaccines and therapeutic options are available, some patients experience severe conditions and need critical care support. Hence, identifying key genes or proteins… read more here.
Keywords: network; protein interaction; severe covid; interaction network ... See more keywords
Rice Responses to Abiotic Stress: Key Proteins and Molecular Mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26030896
Abstract: The intensification of global climate change and industrialization has exacerbated abiotic stresses on crops, particularly rice, posing significant threats to food security and human health. The mechanisms by which rice responds to these stresses are… read more here.
Keywords: abiotic stresses; stress; molecular mechanisms; mechanisms rice ... See more keywords