Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21886
Abstract: The key proteins involved in transcriptional regulation play convergent roles in cellular homeostasis, and their dysfunction mediates aberrant gene expressions that underline the hallmarks of tumorigenesis. As tumor progression is dependent on such abnormal regulation… read more here.
Keywords: targeting key; involved transcriptional; transcriptional regulation; regulation ... See more keywords
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96750-5
Abstract: Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial… read more here.
Keywords: wound healing; identification key; healing cancer; cancer ... See more keywords
Comparative proteomic analysis provides insight into the key proteins as potential targets underlying the effect of malachite green against Ichthyophthirius multifiliis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of fish diseases"
DOI: 10.1111/jfd.13346
Abstract: Target identification is important for drug discovery. Unfortunately, no drug targets have been found in Ichthyophthirius multifiliis until now and further limited development of the novel drug for Ichthyophthiriasis. In this study, an iTRAQ-based quantitative… read more here.
Keywords: malachite green; potential targets; proteomic analysis; ichthyophthirius multifiliis ... See more keywords
Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/6181943
Abstract: Background Insomnia is a sleep disorder and the cause of many healthy problems. However, there are few studies on patients with insomnia and dreaminess at present. Therefore, this study is aimed at exploring the pathological… read more here.
Keywords: insomnia patients; ppi network; patients dreams; reveals molecular ... See more keywords
Nuclear Lamins: Key Proteins for Embryonic Development
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DOI: 10.3390/biology11020198
Abstract: Simple Summary The biology of a multicellular organism is extremely complex, leaving behind a realm of compound yet systematic mechanisms still to be unraveled. The nucleus is a vital cellular organelle adapted to storing and… read more here.
Keywords: nuclear lamins; development; lamins key; proteins embryonic ... See more keywords
Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050690
Abstract: Coronavirus disease 2019 (COVID-19) is still an active global public health issue. Although vaccines and therapeutic options are available, some patients experience severe conditions and need critical care support. Hence, identifying key genes or proteins… read more here.
Keywords: network; protein interaction; severe covid; interaction network ... See more keywords