EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4987
Abstract: As a member of the Ephrin protein family that elicits short distance cell‐cell signaling, EphrinA3 has been shown to promote or inhibit tumorigenesis depending on tumor types, but its roles and the underlying mechanisms in… read more here.
Keywords: ephrina3 key; key regulator; lung adenocarcinoma; regulator malignant ... See more keywords
The AP‐1 pathway; A key regulator of cellular transformation modulated by oncogenic viruses
Sign Up to like & getrecommendations! Published in 2019 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2088
Abstract: Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B… read more here.
Keywords: cellular transformation; oncogenic viruses; regulator cellular; virus ... See more keywords
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.019
Abstract: Summary Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator… read more here.
Keywords: methylation; homologous recombination; prmt5; tip60 ... See more keywords
PACS: 2: A Key Regulator of Mitochondria-Associated Membranes (MAMs).
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105080
Abstract: Mitochondria-associated membranes (MAMs) are the organellar contact sites between mitochondria and the endoplasmic reticulum (ER), and recent studies demonstrated that MAMs, which serve as multiple scaffolds of proteins, are involved in Ca2+ signaling, lipid metabolism,… read more here.
Keywords: mitochondria associated; associated membranes; pacs key; membranes mams ... See more keywords
Ultrabithorax is a key regulator for the dimorphism of wings, a main cause for the outbreak of planthoppers in rice
Sign Up to like & getrecommendations! Published in 2020 at "National Science Review"
DOI: 10.1093/nsr/nwaa061
Abstract: Abstract Rice planthoppers, the most devastating rice pests, occur in two wing forms: the short-wing form for rapid population growth and long-wing form for long-distance migration, which together create the mechanism for outbreak. Here we… read more here.
Keywords: short wing; rice; expression; wing form ... See more keywords
Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13633
Abstract: Cysteinyl aspartate specific proteinase (caspase)-6 belongs to the caspase family and plays a vital role in mediating cell death. Under certain conditions, three pathways of programmed cell death (PCD), including apoptosis, necroptosis, and pyroptosis (PANoptosis),… read more here.
Keywords: key regulator; way; panoptosis; caspase ... See more keywords
Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1606
Abstract: The chromatin state, which undergoes global changes during spermatogenesis, is critical to meiotic initiation and progression. However, the key regulators involved and the underlying molecular mechanisms remain to be uncovered. Here, we report that mouse… read more here.
Keywords: meiosis; key regulator; mouse; mouse spermatogenesis ... See more keywords
UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317692205
Abstract: UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression and tumorigenesis, substantiating its ability to act as a potential biomarker… read more here.
Keywords: uhrf1 key; cancer; cancer therapeutics; regulator epigenetics ... See more keywords
HOTAIR: a key regulator in gynecologic cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0434-6
Abstract: Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb… read more here.
Keywords: gynecologic cancers; hotair key; hotair; regulator gynecologic ... See more keywords
Global discovery of small RNAs in the fish pathogen Edwardsiella piscicida: key regulator of adversity and pathogenicity
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary Research"
DOI: 10.1186/s13567-018-0613-z
Abstract: Recently, bacterial small RNA (sRNA) has been shown to be involved as a key regulator in stress responses. sRNAs of Edwardsiella piscicida, an important aquatic pathogen, are not well characterized to date. In this study,… read more here.
Keywords: adversity pathogenicity; edwardsiella piscicida; piscicida; pathogenicity ... See more keywords
Versican proteolysis as a key regulator of CD8+ T-cell infiltration in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e15082
Abstract: e15082Background: Colorectal cancer (CRC) originates within immunologically complex microenvironments. To date the benefits of immunotherapy have been modest except in neoantigen-laden mismatch rep... read more here.
Keywords: colorectal cancer; proteolysis key; cancer; regulator cd8 ... See more keywords