Dysregulation of NEUROG2 plays a key role in focal cortical dysplasia
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25187
Abstract: Focal cortical dysplasias (FCDs) are an important cause of drug‐resistant epilepsy. In this work, we aimed to investigate whether abnormal gene regulation, mediated by microRNA, could be involved in FCD type II. read more here.
Keywords: role focal; focal cortical; neurog2 plays; dysregulation neurog2 ... See more keywords
The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22983
Abstract: Tranilast, N-(3',4'-dimethoxycinnamoyl)-anthranilic acid, is an anti-allergic drug and is considered for use in the treatment of rheumatoid arthritis. Methotrexate, an antimetabolite and folate antagonist to treat some cancers, is also a first-line drug for RA.… read more here.
Keywords: mtx; drug drug; drug; methotrexate ... See more keywords
Guidelines Have a Key Role in Driving HCV Elimination by Advocating for Simple HCV Care Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Therapy"
DOI: 10.1007/s12325-021-01636-7
Abstract: The availability of pangenotypic direct-acting antivirals for treatment of hepatitis C (HCV) has provided an opportunity to simplify patient pathways. Recent clinical practice guidelines have recognised the need for simplification to ensure that elimination of… read more here.
Keywords: guidelines key; hcv; driving hcv; role driving ... See more keywords
The Emerging Key Role of Klotho in the Hypothalamus–Pituitary–Ovarian Axis
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00277-5
Abstract: The hypothalamus–pituitary–ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of gonadotropin-releasing hormone, follicle-stimulating hormone, or luteinizing hormone, and eventually result in the… read more here.
Keywords: axis; hypothalamus pituitary; klotho; key role ... See more keywords
Key role of different levels of dissolved oxygen in hydrolyzed polyacrylamide bioconversion: Focusing on metabolic products, key enzymes and functional microorganisms.
Sign Up to like & getrecommendations! Published in 2020 at "Bioresource technology"
DOI: 10.1016/j.biortech.2020.123089
Abstract: Dissolved oxygen (DO) played a short board effect on nitrogen biotransformation and pollutant metabolism. This study for the first time explored the key role of different levels of DO (covering anaerobic, anoxic and aerobic) on… read more here.
Keywords: bioconversion; hydrolyzed polyacrylamide; different levels; role different ... See more keywords
Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107569
Abstract: Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients… read more here.
Keywords: dengue virus; zikv infection; infection; key role ... See more keywords
Key role of network formation in Rutting, fatigue and brittle performance of bitumen/PEG/MDI/SiO2 composites
Sign Up to like & getrecommendations! Published in 2021 at "Construction and Building Materials"
DOI: 10.1016/j.conbuildmat.2021.123739
Abstract: Abstract The effect of hydrophilic SiO2 content on the rheological property of bitumen (B)/ polyethylene glycol (PEG)/4,4′-diphenylmethane diisocyanate (MDI)/SiO2 composite was investigated. The multiple stress creep and recovery (MSCR) and linear amplitude sweep (LAS) tests… read more here.
Keywords: key role; mdi sio2; performance; peg mdi ... See more keywords
Identification of a miRNAs signature associated with exposure to stress early in life and enhanced vulnerability for schizophrenia: New insights for the key role of miR-125b-1-3p in neurodevelopmental processes
Sign Up to like & getrecommendations! Published in 2019 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2018.07.030
Abstract: Epidemiological and clinical studies have provided evidence for a role of both genetic and environmental factors, such as stressful experiences early in life, in the pathogenesis of Schizophrenia (SZ) and microRNAs (miRNAs) have been suggested… read more here.
Keywords: mir 125b; stress; early life; key role ... See more keywords
Key Role of Defects in Thermoelectric Performance of TiMSn (M = Ni, Pd, and Pt) Half-Heusler Alloys
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.0c03243
Abstract: Half-Heusler alloys are thermoelectric materials that enable direct conversion of waste heat to electricity. A systematic study of these alloys has never been attempted using local Gaussian type or... read more here.
Keywords: heusler alloys; role defects; key role; half heusler ... See more keywords
Key Role of Lorentz Excitation in the Electromagnetic-Enhanced Hydrogen Evolution Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c00643
Abstract: Alternating magnetic fields (AMFs) are recently demonstrated as a promising strategy to promote the electrochemical catalytic reactions. However, the underlying mechanisms are still an open question. In this work, we systematically investigated the influence of… read more here.
Keywords: role lorentz; evolution reaction; key role; hydrogen evolution ... See more keywords
The key role of forests in meeting climate targets requires science for credible mitigation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Climate Change"
DOI: 10.1038/nclimate3227
Abstract: Forest-based climate mitigation may occur through conserving and enhancing the carbon sink and through reducing greenhouse gas emissions from deforestation. Yet the inclusion of forests in international climate agreements has been complex, often considered a… read more here.
Keywords: meeting climate; role forests; science; key role ... See more keywords