Structural visualization of key steps in nucleosome reorganization by human FACT
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46617-7
Abstract: Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and native mass spectrometry (MS) studies revealed novel key steps of nucleosome reorganization conducted by… read more here.
Keywords: steps nucleosome; human fact; fact; nucleosome reorganization ... See more keywords
The Immunomodulator Dimethyl Itaconate Inhibits Several Key Steps of Angiogenesis in Cultured Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415972
Abstract: The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using… read more here.
Keywords: itaconate; endothelial cells; immunomodulator; key steps ... See more keywords
Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components
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DOI: 10.7554/elife.28985
Abstract: FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we define the minimal molecular machinery required for FGF2 membrane translocation in a… read more here.
Keywords: unconventional secretion; fgf2; translocation; membrane ... See more keywords