Integration of metabolomics and transcriptomics to reveal metabolic characteristics and key targets associated with cisplatin resistance in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00209
Abstract: Continuous exposure to cisplatin can induce drug resistance to limit efficacy, however, the underlying mechanisms correlated to cisplatin resistance are still unclear. Drug-sensitive A549 cells and cisplatin-resistant A549/DDP cells were used to explore the potential… read more here.
Keywords: metabolism; key targets; a549 ddp; targets associated ... See more keywords
Uncovering key targets of success for immunotherapy in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.2010044
Abstract: INTRODUCTION Despite available treatment options, pancreatic ductal adenocarcinoma (PDAC) is frequently lethal. Recent immunotherapy strategies have failed to yield any notable impact. Therefore, research is focussed on unearthing new drug targets and therapeutic strategies to… read more here.
Keywords: immunotherapy; uncovering key; immunotherapy pancreatic; key targets ... See more keywords
Huangqi Guizhi Wuwu decoction in peripheral neurotoxicity treatment using network pharmacology and molecular docking
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031281
Abstract: In this study, we predicted the core active compounds of Huangqi Guizhi Wuwu decoction in treatment of oxaliplatin-induced peripheral neuropathy and the related potential mechanism. Corresponding database was used to complete the interaction (PPI) network… read more here.
Keywords: pharmacology; wuwu decoction; huangqi guizhi; guizhi wuwu ... See more keywords
Screening and Molecular Modeling Evaluation of Food Peptides to Inhibit Key Targets of COVID-19 Virus
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DOI: 10.3390/biom11020330
Abstract: Peptide drugs, especially food-derived peptides, have a variety of functional activities including antiviral and may also have a therapeutic effect on COVID-19. In this study, comparing with the reported drugs, 79 peptides were found to… read more here.
Keywords: targets covid; covid virus; amino acids; key targets ... See more keywords
Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44040109
Abstract: Antihistamines have potent efficacy to alleviate COVID-19 (Coronavirus disease 2019) symptoms such as anti-inflammation and as a pain reliever. However, the pharmacological mechanism(s), key target(s), and drug(s) are not documented well against COVID-19. Thus, we… read more here.
Keywords: key target; key targets; antihistamines covid; network pharmacology ... See more keywords