Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 activation
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7749
Abstract: Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to abnormal follicular development and ovulation disorders in polycystic ovary syndrome (PCOS). Carnosol is a plant‐derived polyphenol that has been proven to exhibit several cell… read more here.
Keywords: apoptosis; oxidative stress; polycystic ovary; kgn cells ... See more keywords
Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells.
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DOI: 10.1016/j.chemosphere.2020.126707
Abstract: Bisphenol A (BPA) is gradually being replaced by presumably safer analogues such as bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF), due to its toxic, endocrine disrupting and possible carcinogenic effects. Although these… read more here.
Keywords: bisphenol bisphenol; damage; kgn cells; oxidative stress ... See more keywords
MiR-873-5p regulated LPS-induced oxidative stress via targeting heme oxygenase-1 (HO-1) in KGN cells
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DOI: 10.1039/c8ra06697c
Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. Increasing evidence reveals that PCOS may be associated with an increased level of oxidative stress. This study aimed to explore the… read more here.
Keywords: lps induced; kgn; mir 873; kgn cells ... See more keywords
LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2053797
Abstract: As an endocrine and metabolic disorder, polycystic ovarian syndrome (PCOS) is common in females at childbearing age. Our work was intended to uncover the underlying role of LINC00173 and its potential regulatory mechanism in PCOS… read more here.
Keywords: linc00173; jag1; kgn cells; apoptosis ... See more keywords
Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac030
Abstract: In the ovary, proliferation and differentiation of granulosa cells (GCs) drive follicular growth. Our immunohistochemical study in a non-human primate, the Rhesus monkey, showed that the mitochondrial activity marker protein cytochrome c oxidase subunit 4… read more here.
Keywords: kgn cells; follicular growth; granulosa cells; evidence role ... See more keywords
Abstract 1617: TGFBR1 as a novel therapeutic target in adult granulosa cell tumors
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DOI: 10.1158/1538-7445.am2023-1617
Abstract: Adult granulosa cell tumor (AGCT) is a subtype of sex-cord stromal tumors and accounts for ~5% of all ovarian neoplasms. Nearly 100% of AGCT cases are caused by an oncogenic point mutation in the Forkhead… read more here.
Keywords: kgn cells; cell; adult granulosa; granulosa cell ... See more keywords
IL-15 Participates in the Pathogenesis of Polycystic Ovary Syndrome by Affecting the Activity of Granulosa Cells
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DOI: 10.3389/fendo.2022.787876
Abstract: Background Low-grade chronic inflammation may contribute to the pathogenesis of polycystic ovary syndrome (PCOS). Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the development of chronic inflammation leading to obesity-associated metabolic syndrome. However, the concentration… read more here.
Keywords: kgn cells; syndrome; granulosa cells; pathogenesis ... See more keywords
Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12589
Abstract: Dipeptidyl peptidase 4 (DPP4) has been revealed to be upregulated in women suffering from polycystic ovary syndrome (PCOS), which is a common reproductive disorder. The present study was designed to investigate the effects of inhibition… read more here.
Keywords: cell cycle; expression; kgn cells; creb aromatase ... See more keywords