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   Articles with "kgr" as a keyword



Regulation of STAT3 and NF‐&kgr;B activations by S‐nitrosylation in multiple myeloma

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.02.039

Abstract: Abstract Numerous reports suggest that aberrant activations of STAT3 and NF‐&kgr;B promote survival and proliferation of multiple myeloma (MM) cells. In the present report, we demonstrate that a synthetic S‐nitrosothiol compound, S‐nitroso‐N‐acetylcysteine (SNAC), inhibits proliferation… read more here.

Keywords: kgr; multiple myeloma; snac; cell ... See more keywords
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Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38‐MAPK and TLR4/NF‐&kgr;B signaling pathways

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.11.040

Abstract: ABSTRACT Inflammation plays a pivotal role in the development and progression of diabetic nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens, possesses remarkable anti‐inflammatory, immunoregulatory and antitumor properties. However, the renoprotective effects of… read more here.

Keywords: p38 mapk; kgr; p38; diabetic nephropathy ... See more keywords
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Telbivudine attenuates UUO‐induced renal fibrosis via TGF‐&bgr;/Smad and NF‐&kgr;B signaling

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.11.043

Abstract: ABSTRACT Renal fibrosis yields decreased renal function and is a potent contributor to chronic kidney disease (CKD). Telbivudine (LdT) is an anti–hepatitis B virus (HBV) drug that has been found to steadily improve renal function,… read more here.

Keywords: bgr smad; fibrosis; kgr; renal fibrosis ... See more keywords
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Andrographolide derivative CX‐10 ameliorates dextran sulphate sodium‐induced ulcerative colitis in mice: Involvement of NF‐&kgr;B and MAPK signalling pathways

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.02.012

Abstract: &NA; Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto‐ingredients as… read more here.

Keywords: medicine; kgr; agr; ulcerative colitis ... See more keywords
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Alleviating airway inflammation by inhibiting ERK‐NF‐&kgr;B signaling pathway by blocking Kv1.3 channels

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.07.009

Abstract: &NA; Allergic asthma is a chronic inflammatory disease of the airways. T lymphocytes play an important role in the pathogenesis of asthma. The voltage‐gated Kv1.3 potassium channel is a target for the preferential inhibition of… read more here.

Keywords: asthmatic mice; kgr; airway inflammation; pap ... See more keywords
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IL‐2‐induced NF‐&kgr;B phosphorylation upregulates cation nonselective conductance in human cardiac fibroblasts

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.08.040

Abstract: Purpose Studies of negative ionotropic effects of IL‐2 create the basis for possible IL‐2 impact on nonselective conductance (GNS), which potentially makes these effects useful in elucidation of the pathways affected by IL‐2. Materials and… read more here.

Keywords: stim orai; kgr; cardiac fibroblasts; human cardiac ... See more keywords
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Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII‐dependent mitochondrion‐mediated apoptosis and MAPK/NF‐&kgr;B signaling

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recommendations! Published in 2019 at "Life Sciences"

DOI: 10.1016/j.lfs.2018.11.035

Abstract: Aims: Tilianin, a naturally occurring flavonoid glycoside, possesses versatile biological activities including antioxidant, anti‐inflammatory, energy collecting and anti‐hypoxic effects. Little is known about the mechanisms underlying the effect of tilianin against ischemic injury in neuronal… read more here.

Keywords: mitochondrion mediated; kgr; ischemic injury; camkii ... See more keywords
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TWEAK/Fn14 promotes pro‐inflammatory cytokine secretion in hepatic stellate cells via NF‐&kgr;B/STAT3 pathways

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recommendations! Published in 2017 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2017.04.003

Abstract: HighlightsTWEAK induced the pro‐inflammatory cytokine secretion in HSCs.TWEAK activated NF‐&kgr;B and STAT3 signalling pathways in HSCs.The activation of STAT3 and NF‐&kgr;B interacted in HSCs.The pro‐inflammatory cytokine expression was p65‐ and STAT3‐dependent. Abstract Tumor necrosis factor‐like… read more here.

Keywords: kgr; inflammatory cytokine; stat3; tweak ... See more keywords
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CD8+iTregs attenuate glomerular endothelial cell injury in lupus‐prone mice through blocking the activation of p38 MAPK and NF‐&kgr;B

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recommendations! Published in 2018 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2018.09.006

Abstract: HIGHLIGHTSLPS increased MRL/lpr mice glomerular endothelial cells (lupus‐MGECs) apoptosis and adhesion of monocytes to lupus‐MGECs.CD8+iTregs attenuated lupus‐MGECs apoptosis and inhibited adhesion of monocytes to lupus‐MGECs.CD8+iTregs attenuated LPS‐induced lupus‐MGECs injury through blocking the activation of p38… read more here.

Keywords: kgr; cd8 itregs; lupus mgecs; adhesion ... See more keywords
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Cadmium‐induced IL‐6 and IL‐8 expression and release from astrocytes are mediated by MAPK and NF‐&kgr;B pathways

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recommendations! Published in 2017 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2017.03.001

Abstract: HIGHLIGHTSCadmium accumulated in cultured human astrocytes.Cadmium, at non‐toxic concentrations, stimulated IL‐6 and IL‐8 release from cultured human astrocytes.Inhibition of ERK1/2 and NF‐&kgr;B pathways decreased cadmium‐induced IL‐6 production in cultured human astrocytes.Inhibition of ERK1/2, p38 MAPK… read more here.

Keywords: cadmium induced; production; kgr; human astrocytes ... See more keywords
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Involvement of the p38 MAPK signaling pathway in overexpression of matrix metalloproteinase‐9 during the course of brain edema in 1,2‐dichloroethane‐intoxicated mice

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recommendations! Published in 2018 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2018.07.022

Abstract: &NA; Accumulated data have revealed that subacute poisoning of 1,2‐dichloroethane (1,2‐DCE), an industrial solvent used in some countries can cause encephalopathy, in which brain edema is the main pathological change. However, the underlying mechanisms are… read more here.

Keywords: brain edema; kgr; p38; signaling pathway ... See more keywords