m6A methyltransferase KIAA1429 acts as an oncogenic factor in colorectal cancer by regulating SIRT1 in an m6A-dependent manner
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DOI: 10.1038/s41420-022-00878-w
Abstract: N6-methyladenosine (m6A) modifications of RNAs are involved in various aspects of colorectal carcinogenesis via regulation of mRNA stability, splicing, and translation. KIAA1429, an m6A methyltransferase, was found deregulated in multiple cancer types. However, its role… read more here.
Keywords: cancer; kiaa1429; colorectal cancer; m6a methyltransferase ... See more keywords
N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner
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DOI: 10.1080/21655979.2022.2065952
Abstract: ABSTRACT Emerging evidence has emphasized the critical roles played by N6-methyladenosine RNA (m6A) modification in colorectal carcinoma (CRC) initiation and progression. However, the roles and mechanism of m6A and KIAA1429 in CRC progression require further… read more here.
Keywords: manner; aerobic glycolysis; crc; kiaa1429 ... See more keywords
KIAA1429 regulates alternative splicing events of cancer-related genes in hepatocellular carcinoma
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DOI: 10.3389/fonc.2022.1060574
Abstract: Hepatocellular carcinoma (HCC) remains one of the most fatal malignancies with high morbidity and mortality rates in the world, whose molecular pathogenesis is incompletely understood. As an RNA-binding protein participating in the processing and modification… read more here.
Keywords: hepatocellular carcinoma; sequencing data; kiaa1429 regulates; alternative splicing ... See more keywords
m6A Methyltransferase KIAA1429 Regulates the Cisplatin Sensitivity of Gastric Cancer Cells via Stabilizing FOXM1 mRNA
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DOI: 10.3390/cancers14205025
Abstract: Simple Summary N6-methyladenosine (m6A) is involved in the development of drug resistance in various cancer types. The role of N6-methyladenosine (m6A) methyltransferase, KIAA1429, in the resistance of gastric cancer to cisplatin is largely unknown. In… read more here.
Keywords: cancer cells; kiaa1429; gastric cancer; m6a ... See more keywords