Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31952
Abstract: Wilms tumor (WT) is the most common kidney cancer in childhood. Mutations in the microprocessor genes DROSHA and DGCR8 have been identified as putative oncogenic drivers, indicating a critical role of aberrant miRNA processing in… read more here.
Keywords: drosha; kidney development; tumor formation; tumor ... See more keywords
Stereological study of developing glomerular forms during human fetal kidney development
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Nephrology"
DOI: 10.1007/s00467-017-3874-2
Abstract: BackgroundHuman fetal kidney development is a complex and stepwise process. The number, shape, size and distribution of glomeruli provide important information on kidney organization. The aim of this study was to quantify glomerular developing forms… read more here.
Keywords: forms human; kidney development; study; fetal kidney ... See more keywords
Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2016.1256358
Abstract: ABSTRACT The cell-surface glycoprotein CD56 has three major isoforms that play important roles in cell adhesion and signaling, which may promote cell proliferation, differentiation, survival, or migration. It is an important molecule in normal kidney… read more here.
Keywords: normal kidney; cd56 normal; role cd56; kidney development ... See more keywords
MicroRNAs in kidney development and disease
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158277
Abstract: MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate gene expression at the posttranscriptional level, through both translational repression and mRNA destabilization. They are key regulators of kidney morphogenesis, modulating diverse… read more here.
Keywords: kidney; development disease; micrornas kidney; kidney development ... See more keywords
Does Renal Repair Recapitulate Kidney Development?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016070748
Abstract: Over a decade ago, it was proposed that the regulation of tubular repair in the kidney might involve the recapitulation of developmental pathways. Although the kidney cannot generate new nephrons after birth, suggesting a low… read more here.
Keywords: kidney development; repair kidney; renal repair; repair ... See more keywords
Single-Cell RNA Sequencing Reveals mRNA Splice Isoform Switching during Kidney Development.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019080770
Abstract: BACKGROUND During mammalian kidney development, nephron progenitors undergo a mesenchymal-to-epithelial transition and eventually differentiate into the various tubular segments of the nephron. Recently, Drop-seq single-cell RNA sequencing technology for measuring gene expression from thousands of… read more here.
Keywords: cell rna; cell; single cell; rna sequencing ... See more keywords
3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2020081204
Abstract: BACKGROUND The extracellular matrix (ECM) is a network of proteins and glycosaminoglycans that provides structural and biochemical cues to cells. In the kidney, the ECM is critical for nephrogenesis; however, the dynamics of ECM composition… read more here.
Keywords: matrix; kidney development; basement membrane; interstitial matrix ... See more keywords
Adhesion GPCRs in Kidney Development and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00009
Abstract: Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, kidney cancer represents 5% of all new diagnosed cancers. As currently no effective therapies exist… read more here.
Keywords: development disease; kidney development; disease; adhesion gpcrs ... See more keywords
Assessing kidney development and disease using kidney organoids and CRISPR engineering
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.948395
Abstract: The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the biggest scientific advances in regenerative medicine. Kidney organoids have not only laid the groundwork for various organ-like tissue systems but also… read more here.
Keywords: kidney; development; kidney organoids; kidney development ... See more keywords