Learning Physiology From Inherited Kidney Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological reviews"
DOI: 10.1152/physrev.00008.2018
Abstract: The identification of genes causing inherited kidney diseases yielded crucial insights in the molecular basis of disease and improved our understanding of physiological processes that operate in the kidney. Monogenic kidney disorders are caused by… read more here.
Keywords: learning physiology; inherited kidney; physiology; physiology inherited ... See more keywords
Thyroid Parameters and Kidney Disorder in Type 2 Diabetes: Results from the METAL Study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes Research"
DOI: 10.1155/2020/4798947
Abstract: Objective Diabetic kidney disease is one of the most common microvascular complications of diabetes mellitus. We aimed to analyze the association of thyroid parameters with kidney disorders, especially in euthyroid participants. Methods The data were… read more here.
Keywords: thyroid parameters; ft3; type diabetes; kidney disorders ... See more keywords
Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2022080862
Abstract: A number of genetic kidney diseases can now be replicated experimentally, using kidney organoids generated from human pluripotent stem cells. This methodology holds great potential for drug discovery. Under in vitro conditions, however, kidney organoids… read more here.
Keywords: organoid xenografts; methodology; genetic kidney; kidney organoid ... See more keywords
State of the Science for Kidney Disorders in Phelan-McDermid Syndrome: UPK3A, FBLN1, WNT7B, and CELSR1 as Candidate Genes
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061042
Abstract: Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder caused by chromosomal rearrangements affecting the 22q13.3 region or by SHANK3 pathogenic variants. The scientific literature suggests that up to 40% of individuals with PMS have kidney disorders,… read more here.
Keywords: candidate genes; kidney; phelan mcdermid; mcdermid syndrome ... See more keywords
Altered Serum Uric Acid Levels in Kidney Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111891
Abstract: Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or hypouricemia, including their pathophysiology, are discussed. Chronic… read more here.
Keywords: serum uric; disease; acid; kidney disorders ... See more keywords