Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β‐catenin signaling in rats
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23754
Abstract: Exposure to atrazine (ATR), a widely‐used herbicide, is a potential harmful to human health due to its long‐term environmental persistence and bioaccumulation. The effects of chronic exposure to ATR on renal function in rats were… read more here.
Keywords: kidney fibrosis; wnt catenin; atr; atrazine ... See more keywords
Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110473
Abstract: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis. Although Stat3 deletion in tubular epithelial cells is known to protect mice from fibrosis, vFoxd1… read more here.
Keywords: stat3; fibrosis; kidney fibrosis; deletion stat3 ... See more keywords
Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173755
Abstract: CTRP6, a newly identified adiponectin analogue, has been shown to be involved in inflammation, diabetes and cardiovascular diseases. Recently, increasing evidence has shown that CTRP6 plays a critical role in fibrotic diseases, such as myocardial… read more here.
Keywords: fibrosis; kidney fibrosis; ctrp6; fao ... See more keywords
Porcupine's dilemma in kidney fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.07.020
Abstract: Aberrant activation of Wnt/β-catenin signaling, an activity that is critically modulated by porcupine, a membrane-bound O-acyltransferase, is profibrotic. Previously, the Crowley laboratory demonstrated that oral administration of porcupine inhibitor attenuated experimental mouse kidney fibrosis. Now… read more here.
Keywords: porcupine; fibrosis; porcupine dilemma; kidney fibrosis ... See more keywords
Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Kidney international"
DOI: 10.1016/j.kint.2022.01.030
Abstract: Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.… read more here.
Keywords: mfn2; kidney fibrosis; mitofusin; macrophage ... See more keywords
The mTOR inhibitor everolimus attenuates tacrolimus-induced renal interstitial fibrosis in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120150
Abstract: AIMS Tacrolimus-a widely used immunosuppressant to prevent allograft rejection after organ transplantation-is nephrotoxic, increasing the risk of kidney injury accompanied by kidney fibrosis. The mammalian target of rapamycin (mTOR) inhibitor, everolimus, is an immunosuppressant used… read more here.
Keywords: everolimus; fibrosis; induced kidney; kidney fibrosis ... See more keywords
T-2 Toxin Induces Kidney Fibrosis via the mtROS-NLRP3-Wnt/β-Catenin Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05816
Abstract: T-2 toxin causes kidney fibrosis. Wnt/β-catenin signaling promotes kidney fibrosis when sustained and activated. However, whether T-2-induced kidney fibrosis involves Wnt/β-catenin signaling activation has not been explored yet. T-2 toxin causes renal mitochondrial damage, leading… read more here.
Keywords: kidney fibrosis; wnt catenin; toxin; catenin signaling ... See more keywords
Autophagy activation contributes to lipid accumulation in tubular epithelial cells during kidney fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0065-2
Abstract: Sustained activation of autophagy and lipid accumulation in tubular epithelial cells (TECs) are both associated with the kidney fibrosis progression. Autophagy has been found involved in the lipid metabolism regulation through a bi-directional mechanism of… read more here.
Keywords: accumulation; lipid accumulation; kidney fibrosis; autophagy ... See more keywords
Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02864-1
Abstract: Tumor necrosis factor (TNF)-α is a potent mediator of inflammation and is involved in the pathophysiology of chronic kidney disease (CKD). However, the effects of TNF-α inhibition on the progression of kidney fibrosis have not… read more here.
Keywords: kidney fibrosis; inhibition; tumor necrosis; inflammation ... See more keywords
Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20180882
Abstract: Kidney fibrosis is the common pathophysiological mechanism in end-stage renal disease characterized by excessive accumulation of myofibroblast-derived extracellular matrix. Natriuretic peptides have been demonstrated to have cyclic guanosine monophosphate (cGMP)-dependent anti-fibrotic properties likely due to… read more here.
Keywords: kidney fibrosis; cgmp; receptor; kidney ... See more keywords
Effects of contralateral nephrectomy timing and ischemic conditions on kidney fibrosis after unilateral kidney ischemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2126790
Abstract: Abstract Acute kidney injury (AKI) is an important cause of chronic kidney disease (CKD), but the underlying mechanisms are unclear. Animal models are tools for studying the AKI-CKD progression. Kidney ischemia-reperfusion injury (IRI) models, especially… read more here.
Keywords: kidney fibrosis; contralateral nephrectomy; kidney; kidney ischemia ... See more keywords