HIF‐Mediated Fructose Metabolism and Disease Progression in the Cardiovascular‐Kidney‐Metabolic Syndrome
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DOI: 10.1002/cph4.70033
Abstract: The ‘Cardiovascular‐Kidney‐Metabolic Syndrome’ which is characterized by multi‐organ dysfunction ultimately resulting in adverse cardiac outcomes, serves to highlight the importance of organ crosstalk in pathophysiology. The cellular metabolism of fructose, regulated by Ketohexokinase‐C with associated… read more here.
Keywords: physiology; kidney metabolic; metabolism; cardiovascular kidney ... See more keywords
Machine Learning‐Assisted Analysis of Sublingual Microcirculatory Dysfunction for Early Cardiovascular Risk Evaluation and Cardiovascular‐Kidney‐Metabolic Syndrome Stage in Patients With Type 2 Diabetes Mellitus
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DOI: 10.1002/dmrr.3835
Abstract: To examine whether sublingual microcirculation can be used as an effective and noninvasive method for assessing cardiovascular, kidney, and metabolic risks in patients with type 2 diabetes mellitus (T2DM). read more here.
Keywords: patients type; diabetes mellitus; type diabetes; kidney metabolic ... See more keywords
Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death across cardio‐kidney‐metabolic diseases: A meta‐analysis of randomized clinical trials
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DOI: 10.1002/ejhf.3647
Abstract: AIMS Sudden cardiac death (SCD) is a prevalent cause of mortality among patients with cardio-kidney-metabolic (CKM) diseases. Mineralocorticoid receptor antagonists (MRAs) reduce the risk of SCD in patients with left ventricular dysfunction, but it is… read more here.
Keywords: sudden cardiac; meta analysis; cardio kidney; analysis ... See more keywords
Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.
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DOI: 10.1093/eurjpc/zwaf396
Abstract: AIMS Cardiovascular-kidney-metabolic (CKM) syndrome describes the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. While this framework advances our understanding of interrelated pathophysiology across multiple organ systems, further exploring the liver's role may… read more here.
Keywords: kidney metabolic; syndrome; ckm syndrome; cardiovascular kidney ... See more keywords
Heavy metals and mortality in cardiovascular-kidney-metabolic syndrome: Insights from the NHANES cohort
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DOI: 10.1097/md.0000000000046298
Abstract: Cardiovascular-kidney-metabolic (CKM) syndrome is a high-risk condition, but the effect of environmental heavy metal exposure on long-term mortality in this population remains unclear. Data from 14,967 U.S. adults with CKM syndrome from National Health and… read more here.
Keywords: risk; mortality; kidney metabolic; ckm syndrome ... See more keywords
Association Between Serum Advanced Glycation End Products and Cardiovascular‐Kidney‐Metabolic (CKM) Syndrome: A 3‐Year Longitudinal Cohort Study (2019–2022)
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DOI: 10.1111/1753-0407.70137
Abstract: Cardiovascular‐kidney‐metabolic (CKM) syndrome begins with obesity and glucose abnormalities, advancing to cardiovascular and kidney complications. This study investigates the relationship of advanced glycation end products (AGEs) with CKM syndrome staging and transition patterns. read more here.
Keywords: advanced glycation; kidney metabolic; ckm syndrome; cardiovascular kidney ... See more keywords
Kidney-Metabolic Factors Associated with Cognitive Impairment in Chronic Kidney Disease: A Pilot Study
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DOI: 10.1159/000524166
Abstract: Introduction: The associations of kidney-metabolic biomarkers with cognitive impairment (CI) beyond the estimated glomerular filtration rate (eGFR, in mL/min/1.73 m2) and albuminuria levels are not well understood. In exploratory analysis, our objective was to determine… read more here.
Keywords: metabolic factors; kidney; chronic kidney; cognitive impairment ... See more keywords
Abstract 4362320: Relationship between the Cardiovascular-Kidney-Metabolic Syndrome Stages and Cardiovascular Adverse Outcomes in the Beijing Community Population
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DOI: 10.1161/circ.152.suppl_3.4362320
Abstract: Background: Among Asian populations, there have been limited reports on the impact of cardiovascular-kidney-metabolic (CKM) syndrome stages on adverse cardiovascular outcomes. This study aims to explore the association between CKM stages and adverse cardiovascular outcomes… read more here.
Keywords: risk; kidney metabolic; population; syndrome stages ... See more keywords
Abstract 4366246: Association of Cardiovascular-Kidney-Metabolic Syndrome Severity with Low Bone Mineral Density: NHANES 2005-2018
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DOI: 10.1161/circ.152.suppl_3.4366246
Abstract: Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a newly defined framework describing the interconnected pathophysiology of obesity, metabolic dysfunction, kidney disease, and cardiovascular complications. CKM may negatively impact bone health through chronic inflammation, insulin resistance, and adipokine… read more here.
Keywords: kidney metabolic; bmd; cardiovascular kidney; low bone ... See more keywords
In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome
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DOI: 10.1161/circresaha.125.325497
Abstract: Cardiovascular-kidney-metabolic syndrome is a progressive disorder driven by perturbed interorgan crosstalk among adipose, liver, kidney, and heart, leading to multiorgan dysfunction. Capturing the complexity of human cardiovascular-kidney-metabolic syndrome pathophysiology using conventional models has been challenging.… read more here.
Keywords: interorgan crosstalk; kidney metabolic; cardiovascular kidney; kidney ... See more keywords
CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes
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DOI: 10.1186/s12933-024-02180-8
Abstract: The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on… read more here.
Keywords: summit; kidney metabolic; cvot summit; cardiovascular kidney ... See more keywords