Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Cell and Tissue Research"
DOI: 10.1007/s00441-021-03499-4
Abstract: Acute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At… read more here.
Keywords: kidney organoid; kidney diseases; immune mediated; mediated kidney ... See more keywords
A single-cell multiomic analysis of kidney organoid differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219699120
Abstract: Significance During development, changes in chromatin structure regulate gene expression dynamics. A detailed understanding of gene regulatory networks will improve our understanding of organogenesis and disease mechanisms. Using single-nucleus RNA-sequencing (snRNA-seq) and assay for transposase-accessible… read more here.
Keywords: kidney organoid; organoid differentiation; single cell;
Identification of predictive markers for the generation of well-differentiated human induced pluripotent stem cell-derived kidney organoids.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0197
Abstract: Human-induced pluripotent stem cell (iPSC) derived kidney organoids have the potential to advance studies to kidney development and disease. However, reproducible generation of kidney organoids is a challenge. A large variability in the percentage of… read more here.
Keywords: kidney organoid; kidney organoids; well differentiated; expression ... See more keywords
Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2022080862
Abstract: A number of genetic kidney diseases can now be replicated experimentally, using kidney organoids generated from human pluripotent stem cells. This methodology holds great potential for drug discovery. Under in vitro conditions, however, kidney organoids… read more here.
Keywords: organoid xenografts; methodology; genetic kidney; kidney organoid ... See more keywords