Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103526
Abstract: Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive potential for disease modelling and regenerative medicine. However, the limited vascularization and immaturity of kidney organoids have been still remained to overcome. Extracellular matrix… read more here.
Keywords: extracellular matrix; kidney; kidney organoids; kidney decm ... See more keywords
An optimal serum-free defined condition for in vitro culture of kidney organoids.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.098
Abstract: Kidney organoid is an emerging topic of importance for research in kidney development and regeneration. Conventional culture systems for kidney organoids reported thus far use culture media containing serum, which may compromise our understanding and… read more here.
Keywords: ksr; kidney organoids; condition; serum free ... See more keywords
A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.141
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder which manifests progressive renal cyst formation and leads to end-stage kidney disease. Around 85% of cases are caused by PKD1 heterozygous mutations, exhibiting relatively poorer… read more here.
Keywords: novel adpkd; kidney organoids; adpkd model; disease ... See more keywords
Generation of infant- and pediatric-derived urinary induced pluripotent stem cells competent to form kidney organoids
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0618-y
Abstract: Background Human induced pluripotent stem cells (iPSCs) are a promising tool to investigate pathogenic mechanisms underlying human genetic conditions, such as congenital anomalies of the kidney and urinary tract (CAKUT). Currently, iPSC-based research in pediatrics… read more here.
Keywords: kidney organoids; pluripotent stem; induced pluripotent; stem cells ... See more keywords
Accelerating maturation of kidney organoids.
Sign Up to like & getrecommendations! Published in 2019 at "Nature Materials"
DOI: 10.1038/s41563-019-0326-3
Abstract: A two-step method has been developed for the accelerated and efficient generation of human kidney organoids using in vitro and in ovo culture in a three-dimensional environment. read more here.
Keywords: kidney organoids; kidney; accelerating maturation; maturation kidney ... See more keywords
Identification of predictive markers for the generation of well-differentiated human induced pluripotent stem cell-derived kidney organoids.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0197
Abstract: Human-induced pluripotent stem cell (iPSC) derived kidney organoids have the potential to advance studies to kidney development and disease. However, reproducible generation of kidney organoids is a challenge. A large variability in the percentage of… read more here.
Keywords: kidney organoid; kidney organoids; well differentiated; expression ... See more keywords
Building kidney organoids from pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000807
Abstract: Purpose of review During embryogenesis, the kidney is mainly generated from three progenitor cells; nephron progenitors, ureteric bud progenitors and stromal progenitors. Mutual interactions of the all three progenitor populations are essential to form a… read more here.
Keywords: pluripotent stem; kidney; kidney organoids; organoids pluripotent ... See more keywords
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abj4772
Abstract: Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results in… read more here.
Keywords: kidney organoids; injury; repair; intrinsic repair ... See more keywords
Tissue Culture Models of Acute Kidney Injury: From Tubule Cells to Human Kidney Organoids.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2021050693
Abstract: Acute kidney injury (AKI) affects approximately 13.3 million people around the world each year, causing chronic kidney disease and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal renal damage and regenerative therapies for… read more here.
Keywords: kidney; kidney organoids; human kidney; tissue culture ... See more keywords
Assessing kidney development and disease using kidney organoids and CRISPR engineering
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.948395
Abstract: The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the biggest scientific advances in regenerative medicine. Kidney organoids have not only laid the groundwork for various organ-like tissue systems but also… read more here.
Keywords: kidney; development; kidney organoids; kidney development ... See more keywords
Live functional assays reveal longitudinal maturation of transepithelial transport in kidney organoids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.978888
Abstract: Kidney organoids derived from hPSCs have opened new opportunities to develop kidney models for preclinical studies and immunocompatible kidney tissues for regeneration. Organoids resemble native nephrons that consist of filtration units and tubules, yet little… read more here.
Keywords: maturation; kidney; kidney organoids; functional assays ... See more keywords