Thermoforming for Small Feature Replication in Melt Electrowritten Membranes to Model Kidney Proximal Tubule
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401800
Abstract: A novel approach merging melt electrowriting (MEW) with matched die thermoforming to achieve scaffolds with micron‐sized curvatures (200 – 800 µm versus 1000 µm of mandrel printing) for in vitro modeling of the kidney proximal… read more here.
Keywords: kidney proximal; thermoforming small; small feature; proximal tubule ... See more keywords
Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800412
Abstract: The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on… read more here.
Keywords: kidney proximal; fabrication kidney; proximal tubule; tubule grafts ... See more keywords
Inducible nitric oxide synthase-derived nitric oxide promotes mitochondrial dysfunction, altered nutrient metabolism, and apoptosis in Ctns null kidney proximal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.221
Abstract: Nitric oxide (NO) has been shown to play an important role in renal physiology and pathophysiology partly through its influence on various solute transport systems in the kidney proximal tubule. Coincidentally, the same transport systems… read more here.
Keywords: apoptosis; ctns null; nutrient metabolism; kidney proximal ... See more keywords
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0510
Abstract: The kidney proximal tubule (PT) elaborates a uniquely high capacity apical endocytic pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier. Megalin and cubilin/amnionless (CUBAM) receptors engage Dab2 in these cells… read more here.
Keywords: megalin; megalin cubilin; endocytic pathway; dab2 ... See more keywords
Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System
Sign Up to like & getrecommendations! Published in 2022 at "Nephron"
DOI: 10.1159/000526369
Abstract: The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from… read more here.
Keywords: megalin; tubule; renin angiotensin; kidney proximal ... See more keywords
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Health Perspectives"
DOI: 10.1289/ehp7612
Abstract: Background: Understanding the epidemic of chronic kidney disease of uncertain etiology may be critical for health policies and public health responses. Recent studies have shown that microplastics (MPs) contaminate our food chain and accumulate in… read more here.
Keywords: tubular epithelial; human kidney; kidney proximal; stress ... See more keywords
Ceramide-1-Phosphate as a Potential Regulator of the Second Sodium Pump from Kidney Proximal Tubules by Triggering Distinct Protein Kinase Pathways in a Hierarchic Way
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44030066
Abstract: Kidney proximal tubules are a key segment in the reabsorption of solutes and water from the glomerular ultrafiltrate, an essential process for maintaining homeostasis in body fluid compartments. The abundant content of Na+ in the… read more here.
Keywords: kidney proximal; protein kinase; atpase; ceramide phosphate ... See more keywords
Unexpected Enhancement of Cytotoxicity of Cisplatin in a Rat Kidney Proximal Tubular Cell Line Overexpressing Mitochondrial Glutathione Transport Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041993
Abstract: In previous studies, we identified the two principal transporters that mediate the uptake of glutathione (GSH) from cytoplasm into the mitochondrial matrix of rat kidney proximal tubular cells. We hypothesized that genetic modulation of transporter… read more here.
Keywords: proximal tubular; kidney proximal; cisplatin; glutathione ... See more keywords
Characterization of Ceramide Kinase from Basolateral Membranes of Kidney Proximal Tubules: Kinetics, Physicochemical Requirements, and Physiological Relevance
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262110373
Abstract: Ceramide kinase (CerK) catalyzes the phosphorylation of ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid with diverse signaling roles. While CerK has been identified in several cellular compartments, its presence and functional significance in kidney proximal… read more here.
Keywords: kidney proximal; ceramide; ceramide kinase; proximal tubules ... See more keywords
Extract of Red Okra Pod (Abelmoschus esculentus L. Moench) Chemoprevents N-Methyl-N-Nitrosourea-Induced Kidney Proximal Tubular Cells Damage
Sign Up to like & getrecommendations! Published in 2024 at "HAYATI Journal of Biosciences"
DOI: 10.4308/hjb.31.6.1061-1070
Abstract: N-Methyl-N-Nitrosourea (MNU) is a compound that induces oxidative stress resulting in high levels of oxidants and damage to body cells. Red okra contains polyphenol and flavonoid active ingredients as antioxidants. This study aims to analyze… read more here.
Keywords: kidney proximal; okra; extract red; methyl nitrosourea ... See more keywords