Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+ breast cancer
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DOI: 10.1007/s10549-018-4978-5
Abstract: PurposeIdentification of effective and reliable biomarkers that could be used to predict the efficacy of endocrine therapy is of crucial importance to the management of oestrogen receptor positive (ER+) breast cancer (BC). KIF18A, a key… read more here.
Keywords: endocrine therapy; kif18a; benefit endocrine; biomarker ... See more keywords
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
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DOI: 10.1021/acs.jmedchem.1c02030
Abstract: Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been… read more here.
Keywords: mitotic kinesin; kif18a; kinesin kif18a; chemical ... See more keywords
Abstract 4965: Targeting the mitotic kinesin, KIF18A, in chromosomally unstable cancers
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DOI: 10.1158/1538-7445.am2023-4965
Abstract: Background: Chromosome instability (CIN), characterized by frequent and ongoing loss or gain of chromosome number, is commonly observed in tumor cells. Although long recognized as a vulnerability of cancer cells, potential CIN-selective therapeutic targets have… read more here.
Keywords: small molecule; mitotic kinesin; kif18a; kinesin kif18a ... See more keywords
Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers
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DOI: 10.1158/1538-7445.am2023-516
Abstract: Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive types of human cancer such as high-grade serous ovarian cancer and triple-negative breast cancer… read more here.
Keywords: inhibitor; amg 650; kif18a; motor ... See more keywords
Abstract 517: Targeting chromosomally unstable tumors with a selective KIF18A inhibitor
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DOI: 10.1158/1538-7445.am2023-517
Abstract: Chromosome instability (CIN) is an attribute of cancer cells that has yet to be fully exploited therapeutically, despite its prevalence across many tumor types and lack of occurrence in normal cells. To identify genes uniquely… read more here.
Keywords: selective kif18a; kif18a inhibitor; kif18a; tumor ... See more keywords
Prognostic Biomarker KIF18A and Its Correlations With Immune Infiltrates and Mitosis in Glioma
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DOI: 10.3389/fgene.2022.852049
Abstract: Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making the identification of glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) is a member of… read more here.
Keywords: cell; mitosis glioma; expression; kif18a ... See more keywords
The Proliferation of Glioblastoma Is Contributed to Kinesin Family Member 18A and Medical Data Analysis of GBM
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DOI: 10.3389/fgene.2022.858882
Abstract: Background: Glioblastoma (GBM) is widely known as a classical kind of malignant tumor originating in the brain with high morbidity and mortality. Targeted therapy has shown great promise in treating glioblastoma, but more promising targets,… read more here.
Keywords: glioblastoma; medical data; proliferation; kif18a ... See more keywords