Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+ breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4978-5
Abstract: PurposeIdentification of effective and reliable biomarkers that could be used to predict the efficacy of endocrine therapy is of crucial importance to the management of oestrogen receptor positive (ER+) breast cancer (BC). KIF18A, a key… read more here.
Keywords: endocrine therapy; kif18a; benefit endocrine; biomarker ... See more keywords
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02030
Abstract: Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been… read more here.
Keywords: mitotic kinesin; kif18a; kinesin kif18a; chemical ... See more keywords
Abstract A030: Discovery and preclinical characterization of novel macrocyclic KIF18A Inhibitors for treatment of chromosomally instable tumors
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-a030
Abstract: Chromosome instability (CIN) and Genetic instability are hallmark features of malignant tumor cells, contributing to tumour progression, drug resistance and metastasis. KIF18A, a member of the kinesin superfamily of motor proteins, is essential for preserving… read more here.
Keywords: kif18a inhibitors; novel macrocyclic; macrocyclic kif18a; chromosomally instable ... See more keywords
Abstract 4965: Targeting the mitotic kinesin, KIF18A, in chromosomally unstable cancers
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DOI: 10.1158/1538-7445.am2023-4965
Abstract: Background: Chromosome instability (CIN), characterized by frequent and ongoing loss or gain of chromosome number, is commonly observed in tumor cells. Although long recognized as a vulnerability of cancer cells, potential CIN-selective therapeutic targets have… read more here.
Keywords: small molecule; mitotic kinesin; kif18a; kinesin kif18a ... See more keywords
Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers
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DOI: 10.1158/1538-7445.am2023-516
Abstract: Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive types of human cancer such as high-grade serous ovarian cancer and triple-negative breast cancer… read more here.
Keywords: inhibitor; amg 650; kif18a; motor ... See more keywords
Abstract 517: Targeting chromosomally unstable tumors with a selective KIF18A inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-517
Abstract: Chromosome instability (CIN) is an attribute of cancer cells that has yet to be fully exploited therapeutically, despite its prevalence across many tumor types and lack of occurrence in normal cells. To identify genes uniquely… read more here.
Keywords: selective kif18a; kif18a inhibitor; kif18a; tumor ... See more keywords
Abstract 3784: Activity of the novel KIF18A inhibitor, ATX-295, is enriched in whole genome doubled ovarian cancer pre-clinical models
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DOI: 10.1158/1538-7445.am2025-3784
Abstract: KIF18A is a plus-end directed kinesin known to play a role in mitosis by facilitating chromosome alignment and spindle microtubule dynamics. Loss of KIF18A has been shown to inhibit cell proliferation in TP53 mutant cells… read more here.
Keywords: cancer; atx 295; cell; ovarian cancer ... See more keywords
KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway
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DOI: 10.1371/journal.pone.0333385
Abstract: The high morbidity and mortality rates of liver cancer prompt us to constantly explore new therapeutic strategies. The arachidonic acid metabolism-related pathways play a crucial regulatory role in the growth, invasion and angiogenesis of liver… read more here.
Keywords: liver cancer; cancer; kif18a; arachidonic acid ... See more keywords
Prognostic Biomarker KIF18A and Its Correlations With Immune Infiltrates and Mitosis in Glioma
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DOI: 10.3389/fgene.2022.852049
Abstract: Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making the identification of glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) is a member of… read more here.
Keywords: cell; mitosis glioma; expression; kif18a ... See more keywords
The Proliferation of Glioblastoma Is Contributed to Kinesin Family Member 18A and Medical Data Analysis of GBM
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.858882
Abstract: Background: Glioblastoma (GBM) is widely known as a classical kind of malignant tumor originating in the brain with high morbidity and mortality. Targeted therapy has shown great promise in treating glioblastoma, but more promising targets,… read more here.
Keywords: glioblastoma; medical data; proliferation; kif18a ... See more keywords