Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24633
Abstract: Kinesin family member 18B (KIF18B) has been regarded as an oncogene that is abnormally overexpressed in some cancers, but its mechanism in esophageal squamous cell carcinoma (ESCC) remains unclear, which is thereby investigated in this… read more here.
Keywords: cell carcinoma; squamous cell; esophageal squamous; kif18b ... See more keywords
The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109306
Abstract: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair. KIF18B is a molecular… read more here.
Keywords: nuclear kinesin; kif18b; dna double; double strand ... See more keywords
Importin α/β promote Kif18B microtubule association and enhance microtubule destabilization activity
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-03-0113
Abstract: Tight regulation of microtubule (MT) dynamics is necessary for proper spindle assembly and chromosome segregation. The MT destabilizing Kinesin-8, Kif18B, controls astral MT dynamics and spindle positioning. Kif18B interacts with importin α/β as well as… read more here.
Keywords: destabilization activity; association; microtubule; kif18b ... See more keywords
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s261894
Abstract: Background The role of kinesin superfamily proteins (KIFs) has been reported in a variety of tumors and KIFs contributed to the proliferation of cancer cells. But few studies were focus on colon adenocarcinoma. Methods Through… read more here.
Keywords: cell proliferation; colon; kif18b; colon adenocarcinoma ... See more keywords
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma
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DOI: 10.2147/ott.s227438
Abstract: Background Kinesin family member 18B (KIF18B) is a member of the kinesin-8 superfamily, and functions as an oncogene in human cancers. However, its expression profile and role in lung adenocarcinoma (LUAD) remain unclear. Materials and… read more here.
Keywords: expression; family member; kinesin family; kif18b ... See more keywords