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   Articles with "kif1a" as a keyword



A Brownian Ratchet Model Explains the Biased Sidestepping of Single-Headed Kinesin-3 KIF1A.

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recommendations! Published in 2019 at "Biophysical journal"

DOI: 10.1016/j.bpj.2019.05.011

Abstract: The kinesin-3 motor KIF1A is involved in long-ranged axonal transport in neurons. To ensure vesicular delivery, motors need to navigate the microtubule lattice and overcome possible roadblocks along the way. The single-headed form of KIF1A… read more here.

Keywords: kif1a; single headed; microtubule lattice; motor ... See more keywords

De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2113795119

Abstract: KIF1A is a kinesin superfamily molecular motor that transports synaptic vesicle precursors in axons. Mutations in Kif1a lead to a group of neuronal diseases called KIF1A-associated neuronal disorder (KAND). KIF1A forms a homodimer and KAND… read more here.

Keywords: synaptic vesicle; disease; kif1a; kand ... See more keywords

Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A

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recommendations! Published in 2020 at "Journal of Virology"

DOI: 10.1128/jvi.01934-19

Abstract: Pseudorabies virus (PRV) is an alphaherpesvirus related to human pathogens herpes simplex viruses 1 and 2 and varicella-zoster virus. Alphaherpesviruses are neuroinvasive pathogens that establish lifelong latent infections in the host peripheral nervous system (PNS).… read more here.

Keywords: kinesin; transport; infection; motor ... See more keywords

Genetic link between KIF1A mutations and amyotrophic lateral sclerosis: evidence from whole-exome sequencing

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recommendations! Published in 2024 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2024.1421841

Abstract: Objectives Genetics have been shown to have a substantial impact on amyotrophic lateral sclerosis (ALS). The ALS process involves defects in axonal transport and cytoskeletal dynamics. It has been identified that KIF1A, responsible for encoding… read more here.

Keywords: whole exome; genetic link; exome sequencing; kif1a ... See more keywords
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The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

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recommendations! Published in 2021 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2021.618098

Abstract: KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in KIF1A have been associated with a wide spectrum of neurological disorders. Here, we report a… read more here.

Keywords: microtubule; kif1a; variant; r169t ... See more keywords

Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency

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recommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2023.1118707

Abstract: Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter SLC6A8, which prevents creatine uptake into the brain, causing mental retardation, expressive… read more here.

Keywords: plcb1; creatine; kif1a; brain ... See more keywords