Generation of universal natural killer cells from a cryopreserved cord blood mononuclear cell‐derived induced pluripotent stem cell library
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13460
Abstract: Natural killer (NK) cells play a key role in innate immunity and are regarded as a promising candidate for cellular immunotherapy. Natural killer cells may be generated from different sources, including induced pluripotent stem cells… read more here.
Keywords: cell; natural killer; killer cells; cord blood ... See more keywords
Nanoscale Mechanosensing of Natural Killer Cells is Revealed by Antigen-Functionalized Nanowires.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201805954
Abstract: Cells sense their environment by transducing mechanical stimuli into biochemical signals. Commonly used tools to study cell mechanosensing provide limited spatial and force resolution. Here, a novel nanowire-based platform for monitoring cell forces is reported.… read more here.
Keywords: mechanosensing natural; natural killer; cells revealed; nanoscale mechanosensing ... See more keywords
Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
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DOI: 10.1002/adma.202108167
Abstract: Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural… read more here.
Keywords: tumor chemoimmunotherapy; natural killer; killer cells; chemoimmunotherapy ... See more keywords
Bioinspired Preservation of Natural Killer Cells for Cancer Immunotherapy
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DOI: 10.1002/advs.201802045
Abstract: Abstract The ability to cryopreserve natural killer (NK) cells has a significant potential in modern cancer immunotherapy. Current cryopreservation protocols cause deterioration in NK cell viability and functionality. This work reports the preservation of human… read more here.
Keywords: natural killer; preservation; cancer immunotherapy; cancer ... See more keywords
Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26529
Abstract: Natural killer (NK) cells are part of a phylogenetically old defense system, which is characterized by its strong cytolytic function against physiologically stressed cells such as tumor cells and virus‐infected cells. Their use in the… read more here.
Keywords: system; natural killer; killer cells; hematological malignancies ... See more keywords
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
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DOI: 10.1002/cac2.12394
Abstract: Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell adoptive immunotherapy in humans has shown modest efficacy. In… read more here.
Keywords: natural killer; killer cells; immune checkpoints; solid tumors ... See more keywords
Nanowire Based Guidance of the Morphology and Cytotoxic Activity of Natural Killer Cells.
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DOI: 10.1002/smll.202007347
Abstract: The cytotoxic activity of natural killer (NK) cells is regulated by many chemical and physical cues, whose integration mechanism is still obscure. Here, a multifunctional platform is engineered for NK cell stimulation, to study the… read more here.
Keywords: cytotoxic; natural killer; activity natural; killer cells ... See more keywords
Characterization and Activation of Fas Ligand-Producing Mouse B Cells and Their Killer Exosomes.
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DOI: 10.1007/978-1-0716-1237-8_9
Abstract: B lymphocytes make several contributions to immune regulation including production of antibodies with regulatory properties, release of immune suppressive cytokines, and expression of death-inducing ligands. A role for Fas ligand (FasL)-expressing "killer" B cells in… read more here.
Keywords: characterization activation; killer; fas ligand; antigen specific ... See more keywords
Natural killer cells in liver diseases
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DOI: 10.1007/s11684-018-0621-4
Abstract: The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infection,… read more here.
Keywords: cells liver; liver diseases; natural killer; liver ... See more keywords
Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma
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DOI: 10.1007/s12072-018-9909-3
Abstract: BackgroundHepatocellular carcinoma (HCC) is common, but remains difficult to treat. Natural killer (NK) cells are cells of the innate immune system that have potent anti-cancer activity. Recent work has shown that stimulation with IL-12/15/18 leads… read more here.
Keywords: carcinoma; hcc; natural killer; cell ... See more keywords
STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02625-x
Abstract: Chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD-NK) is a rare disease with an indolent clinical course, which is characterized by persistent increase in large granular lymphocytes of NK-cell type. A somatic mutation in… read more here.
Keywords: killer cells; natural killer; chronic lymphoproliferative; lymphoproliferative disorder ... See more keywords