Structural characterization of a newly identified pyocin S8, a proteic antibiotic from Pseudomonas aeruginosa with potential therapeutic applications
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.271
Abstract: Development of alternative antibiotic approaches is urgently required with the emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa (Pa) strains. Pyocins are proteic antibiotics produced by Pa for intraspecies competition for resources. Due to its potency and… read more here.
Keywords: pseudomonas aeruginosa; therapeutic applications; pyocin; newly identified ... See more keywords
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00576
Abstract: The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was used… read more here.
Keywords: potency; cell killing; immolation; killing activity ... See more keywords
Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri‐implantation period
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17269
Abstract: Cytochrome P450 26A1 (CYP26A1) plays a vital role in early pregnancy in mice. Our previous studies have found that CYP26A1 affects embryo implantation by modulating natural killer (NK) cells, and that there is a novel… read more here.
Keywords: cytochrome p450; activity; implantation; p450 26a1 ... See more keywords
The comparative in vitro killing activity of tea tree oil versus permethrin on Demodex folliculorum of rosacea patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.14701
Abstract: Demodex mites have been implicated in several cutaneous disorders compelling the research efforts for effective anti‐Demodex therapy. read more here.
Keywords: demodex; comparative vitro; vitro killing; activity tea ... See more keywords
Wine Phenolic Compounds Differently Affect the Host-Killing Activity of Two Lytic Bacteriophages Infecting the Lactic Acid Bacterium Oenococcus oeni
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12111316
Abstract: To provide insights into phage-host interactions during winemaking, we assessed whether phenolic compounds modulate the phage predation of Oenococcus oeni. Centrifugal partition chromatography was used to fractionate the phenolic compounds of a model red wine.… read more here.
Keywords: phage; oenococcus oeni; killing activity; host ... See more keywords